catalog number :
MBS420819
products full name :
Goat anti-ADAM12 Antibody
products short name :
ADAM12
products name syn :
ADAM12; MCMP; MLTN; MLTNA; MCMPMltna; a disintegrin and metalloproteinase domain 12 (meltrin alpha); meltrin alpha; A disintegrin and metalloproteinase domain 12 (Meltrin-alpha; mouse; homolog of); ADAM metallopeptidase domain 12; RP11-295J3.5; ADAM metallopeptidase domain 12; Goat Anti-Adam12 (mouse); MCMP; MLTN; MLTNA; MCMPMltna; a disintegrin and metalloproteinase domain 12 (meltrin alpha); meltrin alpha; A disintegrin and metalloproteinase domain 12 (Meltrin-alpha, mouse, homolog of); ADAM metallopeptidase domain 12; RP11-295J3.5
other names :
disintegrin and metalloproteinase domain-containing protein 12 isoform 1 preproprotein; Disintegrin and metalloproteinase domain-containing protein 12; disintegrin and metalloproteinase domain-containing protein 12; meltrin-alpha; metalloprotease-disintegrin 12 transmembrane; ADAM metallopeptidase domain 12; Meltrin-alpha
products gene name :
ADAM12
other gene names :
ADAM12; ADAM12; MCMP; MLTN; CAR10; MLTNA; MCMPMltna; ADAM12-OT1; MLTN; ADAM 12
uniprot entry name :
ADA12_HUMAN
sequence :
AARPLPVSPARALC
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Immunohistochemistry: In paraffin embedded Human Prostate shows strong cytoplasm staining of a group of secretory epithelial cells. Recommended concentration, 3-5ug/ml. Western Blot: Approx 90kDa band observed in human heart lysates (calculated MW of 99.6kDa according to NP_003465 and 80.5kDa according to NP_067673). Recommended concentration: 0.1-0.3ug/ml. Peptide ELISA: antibody detection limit dilution 1:64000.
other info1 :
Epitope: N Terminus. Immunogen: Peptide with sequence AARPLPVSPARALC, from the N Terminus of the protein sequence according to NP_003465.3; NP_067673.2. Corresponding Immunizing Peptide: Catalog #MBS428369
other info2 :
Important Note: This antibody is expected to recognise both the longer membrane-bound form of human ADAM12 (NP_003465.3) and the shorter soluble ADAM12 splice isoform (NP_067673.2). This antibody does not cross-react with other ADAMS.
ncbi acc num :
NP_003465.3
ncbi gb acc num :
NM_003474.5
ncbi mol weight :
80,263 Da
ncbi pathways :
Disease Pathway 530764!!Notch Signaling Pathway 169345!!Signal Transduction Pathway 477114!!Signaling By EGFR Pathway 106337!!Signaling By EGFR In Cancer Pathway 530768!!Syndecan-4-mediated Signaling Events Pathway 138064
ncbi summary :
This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]