antibody

Goat anti-ABCD1 Antibody

MBS420795

0.1 mg

290 USD

polyclonal

goat

nonconjugated

western blot, enzyme immunoassay

Antibody

Goat anti-ABCD1 Antibody

ABCD1

ABCD1; ATP-binding cassette; sub-family D (ALD); member 1; ABC42; ALD; ALDP; AMN; adrenoleukodystrophy protein; ATP-binding cassette, sub-family D (ALD), member 1; ABC42; ALD; ALDP; AMN; adrenoleukodystrophy protein

ATP-binding cassette sub-family D member 1; ATP-binding cassette sub-family D member 1; ATP-binding cassette sub-family D member 1; adrenoleukodystrophy protein; ATP-binding cassette, sub-family D (ALD), member 1; Adrenoleukodystrophy protein; ALDP

ABCD1

ABCD1; ABCD1; ALD; AMN; ALDP; ABC42; ALD; ALDP

ABCD1_HUMAN

Polyclonal

Goat

Human

745

EDMQRKGYSEQD

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Western Blot: Preliminary experiments gave an approx. 50kDa band in Human Brain (Cerebellum) lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 82.9kDa according to NP_000024.2. The 50kDa band was successfully blocked by incubation with the immunizing peptide. Peptide ELISA: antibody detection limit dilution 1:32000.

Epitope: Internal Region. Immunogen: Peptide with sequence C-EDMQRKGYSEQD, from the internal region of the protein sequence according to NP_000024.2.

Corresponding Immunizing Peptide: Catalog #MBS426387

7262393

NP_000024.2

NM_000033.3

82,937 Da

ABC Transporters Pathway 83035!!ABC Transporters Pathway 436!!ABC-family Proteins Mediated Transport Pathway 106573!!ABCA Transporters In Lipid Homeostasis Pathway 477112!!Beta-oxidation Of Very Long Chain Fatty Acids Pathway 106139!!Linoleic Acid (LA) Metabolism Pathway 645345!!Metabolism Pathway 477135!!Metabolism Of Lipids And Lipoproteins Pathway 160976!!Peroxisomal Lipid Metabolism Pathway 106136!!Peroxisome Pathway 131226

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system. [provided by RefSeq, Jul 2008]

0.1 mg

290 USD