Goat anti-M1 mAChR/CHRM1 Antibody | MyBioSource MBS420792 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-M1 mAChR/CHRM1 Antibody

catalog :

MBS420792

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420792

products type :

Antibody

products full name :

Goat anti-M1 mAChR/CHRM1 Antibody

products short name :

M1 mAChR/CHRM1

products name syn :

CHRM1; M1 mAChR; cholinergic receptor, muscarinic 1; HM1; M1; MGC30125; muscarinic acetylcholine receptor M1; CHRM1 antibody; M1 mAChR antibody; cholinergic receptor; muscarinic 1 antibody; HM1 antibody; M1 antibody; MGC30125 antibody; muscarinic acetylcholine receptor M1 antibody; M1 mAChR / CHRM1

other names :

muscarinic acetylcholine receptor M1; Muscarinic acetylcholine receptor M1; muscarinic acetylcholine receptor M1; cholinergic receptor muscarinic 1

products gene name :

CHRM1

products gene name syn :

M1 mAChR

other gene names :

CHRM1; CHRM1; M1; HM1; M1R

uniprot entry name :

ACM1_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog

sequence length :

460

sequence :

DKRRWRKIPKRPGSVH

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 64000. Western Blot: Approx 50kDa band observed in Mouse Heart and Rat Heart lysates (calculated MW of 51.4kDa according to NP_000729.2). Recommended concentration: 0.3-1ug/ml.

other info1 :

Immunogen: Peptide with sequence C-DKRRWRKIPKRPGSVH, from the C Terminus of the protein sequence according to NP_000729.2. Epitope: C Terminus

ncbi gi num :

37622910

ncbi acc num :

NP_000729.2

ncbi gb acc num :

NM_000738.2

ncbi mol weight :

50,748 Da

ncbi pathways :

Amine Ligand-binding Receptors Pathway (1269553); Calcium Regulation In The Cardiac Cell Pathway (198906); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Cholinergic Synapse Pathway (217716); Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); G Alpha (q) Signalling Events Pathway (1269578); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); GPCRs, Class A Rhodopsin-like Pathway (198886)

ncbi summary :

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]

uniprot summary :

mAChR m1: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily. Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 11q13. Cellular Component: asymmetric synapse; cell junction; dendrite; integral to plasma membrane; membrane; nerve terminal; plasma membrane; postsynaptic density; postsynaptic membrane; synapse. Molecular Function: drug binding; G-protein coupled acetylcholine receptor activity; phosphoinositide phospholipase C activity. Biological Process: acetylcholine receptor signaling, muscarinic pathway; cell proliferation; cognition; G-protein coupled receptor protein signaling pathway; muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway; muscarinic acetylcholine receptor, phospholipase C activating pathway; nervous system development; neuromuscular synaptic transmission; positive regulation of cell proliferation; positive regulation of ion transport; protein kinase C activation; protein modification process; regulation of locomotion; regulation of vascular smooth muscle contraction; saliva secretion; signal transduction; synaptic transmission, cholinergic

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage