catalog number :
MBS420785
products full name :
Goat anti-Survivin / BIRC5 Antibody
products short name :
Survivin/BIRC5
products name syn :
BIRC5; survivin; API4; EPR-1; baculoviral IAP repeat-containing 5 (survivin); apoptosis inhibitor 4; baculoviral IAP repeat-containing 5; baculoviral IAP repeat-containing protein 5; survivin variant 3 alpha; BIRC5; survivin; API4; EPR-1; baculoviral IAP repeat-containing 5 (survivin); apoptosis inhibitor 4; baculoviral IAP repeat-containing 5; baculoviral IAP repeat-containing protein 5; survivin variant 3 alpha
other names :
baculoviral IAP repeat-containing protein 5 isoform 1; Baculoviral IAP repeat-containing protein 5; baculoviral IAP repeat-containing protein 5; apoptosis inhibitor 4; survivin variant 3 alpha; apoptosis inhibitor survivin; baculoviral IAP repeat containing 5; Apoptosis inhibitor 4; Apoptosis inhibitor survivin
products gene name :
BIRC5
other gene names :
BIRC5; BIRC5; API4; EPR-1; API4; IAP4
uniprot entry name :
BIRC5_HUMAN
reactivity :
Human, Cat, Dog, Pig, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 18kDa band observed in Human T cell line MOLT4 lysates (calculated MW of 16.4kDa according to NP_001159.2 and 18.6kDa according to NP_001012271.1). Recommended concentration: 0.01-0.5ug/ml. Peptide ELISA: antibody detection limit dilution 1:16000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence CVRRAIEQLAAMD, from the C Terminus of the protein sequence according to NP_001159.2; NP_001012271.1. Corresponding Immunizing Peptide: Catalog #MBS425577
other info2 :
Important Note: This antibody is expected to recognize the reported isoforms 1 (NP_001159.2) and isoform 3 (NP_001012271.1).
ncbi acc num :
NP_001159.2
ncbi gb acc num :
NM_001168.2
ncbi mol weight :
8,490 Da
ncbi pathways :
Apoptosis Pathway 198797!!Apoptosis Modulation And Signaling Pathway 198822!!Aurora A Signaling Pathway 137925!!Aurora B Signaling Pathway 138080!!Cell Cycle Pathway 530733!!Cell Cycle, Mitotic Pathway 105765!!Colorectal Cancer Pathway 83106!!Colorectal Cancer Pathway 518!!FOXM1 Transcription Factor Network Pathway 137935!!Hepatitis B Pathway 694606
ncbi summary :
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]