antibody

Goat anti-ABCB10 Antibody

MBS420779

0.1 mg

225 USD

polyclonal

goat

nonconjugated

human, mouse, rat

ELISA, enzyme immunoassay

Antibody

Goat anti-ABCB10 Antibody

ABCB10

ABCB10; ATP-binding cassette, sub-family B (MDR/TAP), member 10; EST20237; M-ABC2; MTABC2; ATP-binding cassette, sub-family B, member 10; ABC-me; ABCB10 antibody; ATP-binding cassette; sub-family B (MDR/TAP); member 10 antibody; EST20237 antibody; M-ABC2 antibody; MTABC2 antibody; ATP-binding cassette; sub-family B; member 10 antibody; ABC-me antibody

ATP-binding cassette sub-family B member 10, mitochondrial; ATP-binding cassette sub-family B member 10, mitochondrial; ATP-binding cassette sub-family B member 10, mitochondrial; ATP binding cassette subfamily B member 10; ATP-binding cassette transporter 10; ABC transporter 10 protein; Mitochondrial ATP-binding cassette 2; M-ABC2

ABCB10

ABCB10; ABCB10; M-ABC2; MTABC2; EST20237; ABC transporter 10 protein; M-ABC2

ABCBA_HUMAN

Polyclonal

Goat

Expected from sequence similarity: Human, Mouse, Rat

738

KPNGIYRKLMNKQ

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA)

Peptide ELISA: Antibody detection limit dilution 1: 64000. Western Blot: Preliminary experiments gave bands at approx.90kDa and 50kDa in Human Bone Marrow lysates after 0. 05ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 79.1kDa according to NP_036221.2 and given the expected mature size of ~65kDa according to Graf et al. (PMID: 15215243). Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).

Immunogen: Peptide with sequence C-KPNGIYRKLMNKQ, from the C Terminus of the protein sequence according to NP_036221.2. Epitope: C Terminus

171184400

NP_036221.2

NM_012089.2

79,148 Da

ABC Transporters Pathway (83035); ABC Transporters Pathway (436); ABC-family Proteins Mediated Transport Pathway (1269904); Mitochondrial ABC Transporters Pathway (1269906); Transmembrane Transport Of Small Molecules Pathway (1269903)

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein is unknown. [provided by RefSeq, Jul 2008]

ABCB10: May mediate critical mitochondrial transport functions related to heme biosynthesis. Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily. Protein type: Membrane protein, integral; Transporter, ABC family; Hydrolase; Transporter; Mitochondrial; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 1q42.13. Cellular Component: mitochondrial inner membrane. Molecular Function: ATP binding; ATPase activity, coupled to transmembrane movement of substances; protein homodimerization activity; transporter activity. Biological Process: metabolic process; transmembrane transport; transport

0.1 mg

225 USD