Goat anti-MCL1 Antibody | MyBioSource MBS420762 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-MCL1 Antibody

catalog :

MBS420762

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420762

products type :

Antibody

products full name :

Goat anti-MCL1 Antibody

products short name :

MCL1

products name syn :

MCL1; TM; EAT; MCL1L; MCL1S; MGC1839; MGC104264; myeloid cell leukemia sequence 1 (BCL2-related); induced myeloid leukemia cell differentiation protein Mcl-1; myeloid cell leukemia sequence 1; myeloid cell leukemia sequence 1, isoform 1; BCL2L3; Mcl-1; MCL1 antibody; TM antibody; EAT antibody; MCL1L antibody; MCL1S antibody; MGC1839 antibody; MGC104264 antibody; myeloid cell leukemia sequence 1 (BCL2-related) antibody; induced myeloid leukemia cell differentiation protein Mcl-1 antibody; myeloid cell leukemia sequence 1 antibody; myeloid cell leukemia sequence 1; isoform 1 antibody; BCL2L3 antibody; Mcl-1 antibody

other names :

induced myeloid leukemia cell differentiation protein Mcl-1 isoform 1; Induced myeloid leukemia cell differentiation protein Mcl-1; induced myeloid leukemia cell differentiation protein Mcl-1; myeloid cell leukemia 1; Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EAT

products gene name :

MCL1

other gene names :

MCL1; MCL1; TM; EAT; MCL1L; MCL1S; Mcl-1; BCL2L3; MCL1-ES; bcl2-L-3; mcl1/EAT; BCL2L3; Bcl2-L-3

uniprot entry name :

MCL1_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow

sequence length :

350

sequence :

AGVGAGLAYLIR

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 2000. Western Blot: Approx 35kDa band observed in lysates of Human Lung, in Mouse and Rat Thymus, and in cell line K562 (calculated MW of 37.3kDa according to NP_068779.1). Recommended concentration: 1-3ug/ml.

other info1 :

Immunogen: Peptide with sequence C-AGVGAGLAYLIR, from the C Terminus of the protein sequence according to NP_068779.1; NP_001184249.1. Epitope: C Terminus

other info2 :

Note: This antibody is expected to recognise reported isoform 1 (NP_068779.1) and isoform 3 (NP_001184249.1).

ncbi gi num :

11386165

ncbi acc num :

NP_068779.1

ncbi gb acc num :

NM_021960.4

ncbi mol weight :

28,662 Da

ncbi pathways :

Apoptosis Pathway (198797); Apoptosis Pathway (83060); Apoptosis Pathway (470); Apoptosis Modulation And Signaling Pathway (198822); Direct P53 Effectors Pathway (137939); E2F Transcription Factor Network Pathway (137934); HIF-1-alpha Transcription Factor Network Pathway (138045); IL-7 Signaling Pathway (198857); IL6-mediated Signaling Events Pathway (137932); Jak-STAT Signaling Pathway (83077)

ncbi summary :

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]

uniprot summary :

MCL1: a myeloid cell leukemia protein of the Bcl-2 family of proteins. Two alternatively spliced transcripts encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing. Protein type: Inhibitor; Apoptosis; Membrane protein, integral; Channel, misc.; Mitochondrial. Chromosomal Location of Human Ortholog: 1q21. Cellular Component: cytoplasm; cytosol; integral to membrane; membrane; mitochondrial matrix; mitochondrial outer membrane; mitochondrion; nucleoplasm; nucleus. Molecular Function: BH3 domain binding; protein binding; protein channel activity; protein heterodimerization activity; protein homodimerization activity. Biological Process: apoptotic mitochondrial changes; cell fate determination; cellular homeostasis; DNA damage response, signal transduction resulting in induction of apoptosis; multicellular organismal development; response to cytokine stimulus

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage