catalog number :
MBS420754
products full name :
Goat anti-Alsin / ALS2 Antibody
products short name :
Alsin/ALS2
products name syn :
ALS2; amyotrophic lateral sclerosis 2 (juvenile); ALSJ; PLSJ; IAHSP; KIAA1563; ALS2CR6; FLJ31851; MGC87187; alsin; amyotrophic lateral sclerosis 2 (juvenile); ALSJ; PLSJ; IAHSP; KIAA1563; ALS2CR6; FLJ31851; MGC87187; alsin
other names :
alsin isoform 1; Alsin; alsin; amyotrophic lateral sclerosis 2 protein; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein; amyotrophic lateral sclerosis 2 (juvenile); Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein; Amyotrophic lateral sclerosis 2 protein
products gene name :
ALS2
other gene names :
ALS2; ALS2; ALSJ; PLSJ; IAHSP; ALS2CR6; ALS2CR6; KIAA1563
uniprot entry name :
ALS2_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Cow
sequence :
LKACYYQIQREKLN
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
app notes :
Immunohistochemistry: In paraffin embedded Human Cortex shows pixulate cytoplasm staining in some neuronal cells. Recommended concentration, 3-5ug/ml. Western Blot: No signal obtained yet but low background observed in Human Brain extracts at upto 1ug/ml. Peptide ELISA: antibody detection limit dilution 1:8000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence LKACYYQIQREKLN, from the C Terminus of the protein sequence according to NP_065970.2.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS426900
ncbi acc num :
NP_065970.2
ncbi gb acc num :
NM_020919.3
ncbi mol weight :
86,782 Da
ncbi pathways :
Amyotrophic Lateral Sclerosis (ALS) Pathway 920975!!Amyotrophic Lateral Sclerosis (ALS) Pathway 83099!!Amyotrophic Lateral Sclerosis (ALS) Pathway 511
ncbi summary :
The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]