catalog number :
MBS420750
products full name :
Goat anti-SOD1 Antibody
products short name :
SOD1
products name syn :
SOD1; superoxide dismutase 1; soluble (amyotrophic lateral sclerosis 1 (adult)); HGNC:11179; ALS; ALS1; IPOA; SOD; Cu /Zn superoxide dismutase; Cu/Zn superoxide dismutase; SOD; soluble; indophenoloxidase A; superoxide dismutase (aa 120-154); superoxide dismutase 1; soluble; superoxide dismutase; cystolic; SOD1; superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)); HGNC:11179; ALS; ALS1; IPOA; SOD; Cu /Zn superoxide dismutase; Cu/Zn superoxide dismutase; SOD, soluble; indophenoloxidase A; superoxide dismutase (aa 120-154); superoxide dismutase 1, soluble; superoxide dismutase, cystolic
other names :
superoxide dismutase; Superoxide dismutase [Cu-Zn]; superoxide dismutase [Cu-Zn]; superoxide dismutase [Cu-Zn]; SOD, soluble; indophenoloxidase A; Cu/Zn superoxide dismutase; superoxide dismutase, cystolic; epididymis secretory protein Li 44; superoxide dismutase 1, soluble; Superoxide dismutase 1; hSod1
products gene name :
SOD1
other gene names :
SOD1; SOD1; ALS; SOD; ALS1; IPOA; hSod1; HEL-S-44; homodimer; hSod1
uniprot entry name :
SODC_HUMAN
reactivity :
Human, Mouse, Rat, Dog, etc
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB), ELISA (EIA)
app notes :
Western Blot: Approx 18kDa band observed in Mouse Brain and Rat Spinal Cord lysates, in purified membranes of cell line HeLa and in lysates of NIH3T3. Approx 20kDa observed in HEK293, HepG2 and MCF7 (calculated MW of 15.9kDa according to human NP_000445.1, mouse NP_035564.1 and rat NP_058746.1). Recommended concentration: 0.01-0.03ug/ml. Peptide ELISA: antibody detection limit dilution 1:8000. Enzyme immunoassay: Sandwich-type ELISA with increasing amount of recombinant SOD1 captured by a rabbit antibody. Recommended reporter concentration: 1-2ug/ml
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-SRKHGGPKDEERH, from the internal region of the protein sequence according to NP_000445.1.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS426498
ncbi acc num :
NP_000445.1
ncbi gb acc num :
NM_000454.4
ncbi mol weight :
15,936 Da
ncbi pathways :
AGE/RAGE Pathway 698754!!Amyotrophic Lateral Sclerosis (ALS) Pathway 920975!!Amyotrophic Lateral Sclerosis (ALS) Pathway 83099!!Amyotrophic Lateral Sclerosis (ALS) Pathway 511!!Cellular Responses To Stress Pathway 645258!!Detoxification Of Reactive Oxygen Species Pathway 941400!!Dopamine Metabolism Pathway 920995!!FOXA1 Transcription Factor Network Pathway 137979!!Folate Metabolism Pathway 198833!!Hemostasis Pathway 106028
ncbi summary :
The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]