antibody

Goat anti-ASC / TMS1 Antibody

MBS420732

0.1 mg

290 USD

polyclonal

goat

nonconjugated

western blot, immunohistochemistry, enzyme immunoassay

Antibody

Goat anti-ASC / TMS1 Antibody

ASC/TMS1

PYCARD; ASC; TMS1; PYD and CARD domain containing; CARD5; MGC10332; TMS; apoptosis-associated speck-like protein containing a CARD; caspase recruitment domain protein 5; target of methylation-induced silencing-1; TMS-1; Goat Anti-Pycard (rodent); PYCARD; ASC; TMS1; PYD and CARD domain containing; CARD5; MGC10332; TMS; apoptosis-associated speck-like protein containing a CARD; caspase recruitment domain protein 5; target of methylation-induced silencing-1; TMS-1

apoptosis-associated speck-like protein containing a CARD isoform a; Apoptosis-associated speck-like protein containing a CARD; apoptosis-associated speck-like protein containing a CARD; target of methylation-induced silencing 1; caspase recruitment domain-containing protein 5; PYD and CARD domain containing; Caspase recruitment domain-containing protein 5; PYD and CARD domain-containing protein; Target of methylation-induced silencing 1

PYCARD

PYCARD; PYCARD; ASC; TMS; TMS1; CARD5; TMS-1; ASC; CARD5; TMS1; hASC

ASC_HUMAN

Polyclonal

Goat

Human

195

RESQSYLVEDLERS

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Immunohistochemistry: In paraffin embedded Human Liver shows staining of sinusoidal lining cells. Recommended concentration, 2-4ug/ml. Western Blot: Approx. 22kDa band observed in Hela and Human Kidney lysates (predicted MW of 22kDa according to NP_037390.2). Recommended for use at 1-3ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.

Epitope: C Terminus. Immunogen: Peptide with sequence C-RESQSYLVEDLERS, from the C Terminus of the protein sequence according to NP_037390.2; NP_660183.1. Corresponding Immunizing Peptide: Catalog #MBS425395

Important Note: This antibody is expected to recognise all reported Human isoforms according to NP_037390.2 and NP_660183.1.

10835256

NP_037390.2

NM_013258.4

15,030 Da

Cytosolic DNA-sensing Pathway 125137!!Cytosolic DNA-sensing Pathway 124833!!Direct P53 Effectors Pathway 137939!!Immune System Pathway 106386!!Inflammasomes Pathway 366166!!Influenza A Pathway 217173!!Influenza A Pathway 217150!!Innate Immune System Pathway 106387!!Legionellosis Pathway 469200!!Legionellosis Pathway 469186

This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

0.1 mg

290 USD