Goat anti-MC2R/ACTHR Antibody | MyBioSource MBS420719 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-MC2R/ACTHR Antibody

catalog :

MBS420719

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420719

products type :

Antibody

products full name :

Goat anti-MC2R/ACTHR Antibody

products short name :

MC2R/ACTHR

products name syn :

MC2R; ACTHR; melanocortin 2 receptor (adrenocorticotropic hormone); MGC125798; ACTH receptor; MC2 receptor; adrenocorticotropic hormone receptor; corticotropin receptor; melanocortin 2 receptor; MC2R antibody; ACTHR antibody; melanocortin 2 receptor (adrenocorticotropic hormone) antibody; MGC125798 antibody; ACTH receptor antibody; MC2 receptor antibody; adrenocorticotropic hormone receptor antibody; corticotropin receptor antibody; melanocortin 2 receptor antibody; MC2R / ACTHR

other names :

adrenocorticotropic hormone receptor; Adrenocorticotropic hormone receptor; adrenocorticotropic hormone receptor; melanocortin 2 receptor; Adrenocorticotropin receptor; Melanocortin receptor 2; MC2-R

products gene name :

MC2R

products gene name syn :

ACTHR

other gene names :

MC2R; MC2R; ACTHR; ACTHR; ACTH receptor; ACTH-R; MC2-R

uniprot entry name :

ACTHR_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human

sequence length :

297

sequence :

ENINNTARNNSDC

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 40kDa band observed in Human Skin lysates (calculated MW of 33.9kDa according to NP_000520.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Kilianova et al, Endocrinology.2006 May;147(5): 2325-37; PMID: 16497811). Recommended concentration: 1-3ug/ml.

other info1 :

Immunogen: Peptide with sequence ENINNTARNNSDC, from the N Terminus of the protein sequence according to NP_000520.1. Epitope: N Terminus

ncbi gi num :

4505127

ncbi acc num :

NP_000520.1

ncbi gb acc num :

NM_000529.2

ncbi mol weight :

33,927 Da

ncbi pathways :

Aldosterone Synthesis And Secretion Pathway (1272485); Aldosterone Synthesis And Secretion Pathway (1285075); Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1269004); Disease Pathway (1268854); Diseases Of Metabolism Pathway (1268939); G Alpha (s) Signalling Events Pathway (1269575); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); GPCRs, Class A Rhodopsin-like Pathway (198886)

ncbi summary :

MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014]

uniprot summary :

MC2R: Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase. Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1); also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR. Chromosomal Location of Human Ortholog: 18p11.2. Cellular Component: cytoplasm; integral to plasma membrane; plasma membrane. Molecular Function: adrenocorticotropin receptor activity; melanocortin receptor activity; protein binding. Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; neuropeptide signaling pathway; placenta development; positive regulation of cAMP biosynthetic process. Disease: Glucocorticoid Deficiency 1

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage