Goat anti-ABCE1/ RNAse L inhibitor Antibody | MyBioSource MBS420717 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-ABCE1/ RNAse L inhibitor Antibody

catalog :

MBS420717

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420717

products type :

Antibody

products full name :

Goat anti-ABCE1/ RNAse L inhibitor Antibody

products short name :

ABCE1/ RNAse L

products name syn :

Goat Anti-ABCE1 / RNase L Antibody; ABCE1; RNase L inhibitor; RLI; OABP; ABC38; RNS4I; RNASEL1; RNASELI; ATP-binding cassette, sub-family E (OABP), member 1; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor; HP68; ATP-binding cassette, sub-family E, member 1; ABCE1 antibody; RNase L inhibitor antibody; RLI antibody; OABP antibody; ABC38 antibody; RNS4I antibody; RNASEL1 antibody; RNASELI antibody; ATP-binding cassette; sub-family E (OABP); member 1 antibody; ribonuclease L (2 1; 5 1-oligoisoadenylate synthetase-dependent) inhibitor antibody; HP68 antibody; ATP-binding cassette; sub-family E; member 1 antibody; ABCE1/ RNAse L inhibitor

other names :

ATP-binding cassette sub-family E member 1; ATP-binding cassette sub-family E member 1; ATP-binding cassette sub-family E member 1; ATP binding cassette subfamily E member 1; 2'-5'-oligoadenylate-binding protein; HuHP68; RNase L inhibitor; Ribonuclease 4 inhibitor; RNS4I

products gene name :

ABCE1

products gene name syn :

RNAse L

other gene names :

ABCE1; ABCE1; RLI; OABP; ABC38; RNS4I; RNASEL1; RNASELI; RLI; RNASEL1; RNASELI; RNS4I; RNS4I

uniprot entry name :

ABCE1_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow

sequence length :

599

sequence :

KLNSIKDVEQKK

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Approx.70kDa band observed in lysates of cell lines A431 (calculated MW of 67.6kDa according to NP_002931.1). Recommended concentration: 0.3-1ug/ml.

other info1 :

Immunogen: Peptide with sequence C-KLNSIKDVEQKK, from the C Terminus of the protein sequence according to NP_002931.2; NP_001035809.1. Epitope: C Terminus

other info2 :

Note: Variants (NP_002931.2; NP_001035809.1) encode the same protein.

ncbi gi num :

108773782

ncbi acc num :

NP_002931.2

ncbi gb acc num :

NM_002940.2

ncbi mol weight :

67,314 Da

ncbi pathways :

ABC-family Proteins Mediated Transport Pathway (1269904); Transmembrane Transport Of Small Molecules Pathway (1269903)

ncbi summary :

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

ABCE1: Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. Belongs to the ABC transporter superfamily. ABCE family. Chromosomal Location of Human Ortholog: 4q31. Cellular Component: cytoplasm; membrane; mitochondrial matrix; mitochondrion. Molecular Function: ATP binding; ATPase activity; protein binding; ribonuclease inhibitor activity. Biological Process: negative regulation of catalytic activity; response to virus; RNA catabolic process; transmembrane transport; viral reproduction

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage