catalog number :
MBS420711
products full name :
Goat anti-PAK1 Antibody
products short name :
PAK1
products name syn :
PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog; yeast); MGC130000; MGC130001; PAKalpha; p21-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); MGC130000; MGC130001; PAKalpha; p21-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
other names :
serine/threonine-protein kinase PAK 1 isoform 2; Serine/threonine-protein kinase PAK 1; serine/threonine-protein kinase PAK 1; p65-PAK; alpha-PAK; STE20 homolog, yeast; p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21 protein (Cdc42/Rac)-activated kinase 1; Alpha-PAK; p21-activated kinase 1; PAK-1; p65-PAK
products gene name :
PAK1
other gene names :
PAK1; PAK1; PAKalpha; PAK-1
uniprot entry name :
PAK1_HUMAN
reactivity :
Human, Mouse, Rat, Dog
sequence :
NTEKQKKKPKMSDE
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 70kDa band observed in Human, Mouse and Rat Brain lysates (calculated MW of 60.6kDa according to NP_002567.3). Recommended concentration: 1-3ug/ml. Peptide ELISA: antibody detection limit dilution 1:4000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-NTEKQKKKPKMSDE, from the internal region of the protein sequence according to NP_002567.3. Corresponding Immunizing Peptide: Catalog #MBS425101
other info2 :
Important Note: No cross-reactivity exptected with PAK3
ncbi acc num :
NP_002567.3
ncbi gb acc num :
NM_002576.4
ncbi mol weight :
61,632 Da
ncbi pathways :
Activation Of Rac Pathway 119530!!Adaptive Immune System Pathway 366160!!Alpha6-Beta4 Integrin Signaling Pathway 198807!!Angiopoietin Receptor Tie2-mediated Signaling Pathway 137917!!Aurora A Signaling Pathway 137925!!Axon Guidance Pathway 83065!!Axon Guidance Pathway 476!!Axon Guidance Pathway 105688!!CD28 Co-stimulation Pathway 119553!!CD28 Dependent Vav1 Pathway 119555
ncbi summary :
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]