product summary
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company name :
MyBioSource
product type :
antibody
product name :
Goat anti-APH1A Antibody
catalog :
MBS420705
quantity :
0.1 mg
price :
290 USD
clonality :
polyclonal
host :
goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dog, cow
application :
western blot, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS420705
products type :
Antibody
products full name :
Goat anti-APH1A Antibody
products short name :
APH1A
products name syn :
APH1A; anterior pharynx defective 1 homolog A (C. elegans); 6530402N02Rik; APH-1A; CGI-78; anterior pharynx defective 1 homolog A; anterior pharynx defective 1 homolog A (C. elegans); 6530402N02Rik; APH-1A; CGI-78; anterior pharynx defective 1 homolog A
other names :
gamma-secretase subunit APH-1A isoform 1; Gamma-secretase subunit APH-1A; gamma-secretase subunit APH-1A; aph-1alpha; presenilin-stabilization factor; anterior pharynx defective 1 homolog A; APH1A gamma secretase subunit; Aph-1alpha; Presenilin-stabilization factor
products gene name :
APH1A
other gene names :
APH1A; APH1A; APH-1; APH-1A; CGI-78; 6530402N02Rik; PSF; APH-1a
uniprot entry name :
APH1A_HUMAN
clonality :
Polyclonal
host :
Goat
reactivity :
Human, Mouse, Rat, Dog, Pig, Cow
sequence length :
265
sequence :
HVTDRSDARLQYG
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 26kDa band observed in Human Brain (Cerebral Cortex) lysates (calculated MW of 26.8kDa according to NP_057106.2). Recommended concentration: 0.05-0.1ug/ml. Peptide ELISA: antibody detection limit dilution 1:128000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-HVTDRSDARLQYG, from the internal region of the protein sequence according to NP_001071096.1; NP_057106.2. Corresponding Immunizing Peptide: Catalog #MBS426550
other info2 :
Important Note: This antibody is expected to recognize isoform 1 (NP_001071096.1) and isoform 2 (NP_057106.2).
ncbi gi num :
117606362
ncbi acc num :
NP_001071096.1
ncbi gb acc num :
NM_001077628.2
ncbi mol weight :
20,977 Da
ncbi pathways :
Activated NOTCH1 Transmits Signal To The Nucleus Pathway 576270!!Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Alzheimers Disease Pathway 672448!!Axon Guidance Pathway 105688!!Cell Death Signalling Via NRAGE, NRIF And NADE Pathway 106443!!Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway 771595!!Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway 771593!!Delta-Notch Signaling Pathway 198879!!Developmental Biology Pathway 477129
ncbi summary :
This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011]
size :
0.1 mg
price :
290 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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