antibody

Goat anti-SOCS1 Antibody

MBS420696

0.1 mg

290 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog, cow

western blot, immunohistochemistry, enzyme immunoassay

Antibody

Goat anti-SOCS1 Antibody

SOCS1

SOCS1; JAB; CIS1; SSI1; TIP3; CISH1; Cish1; SSI-1; SOCS-1; suppressor of cytokine signaling 1; JAK binding protein; Tec-interacting protein 3; STAT induced SH3 protein 1; cytokine-inducible SH2 protein 1; SOCS1; JAB; CIS1; SSI1; TIP3; CISH1; Cish1; SSI-1; SOCS-1; suppressor of cytokine signaling 1; JAK binding protein; Tec-interacting protein 3; STAT induced SH3 protein 1; cytokine-inducible SH2 protein 1

suppressor of cytokine signaling 1; Suppressor of cytokine signaling 1; suppressor of cytokine signaling 1; TIP-3; JAK binding protein; JAK-binding protein; Tec-interacting protein 3; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; cytokine-inducible SH2 protein 1; suppressor of cytokine signaling 1; JAK-binding protein; JAB; STAT-induced STAT inhibitor 1; SSI-1; Tec-interacting protein 3; TIP-3

SOCS1

SOCS1; SOCS1; JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; SOCS-1; SSI1; TIP3; SOCS-1; JAB; SSI-1; TIP-3

SOCS1_HUMAN

Polyclonal

Goat

Human, Mouse, Rat, Dog, Cow

211

VLRDYLSSFPFQI

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Immunohistochemistry: In paraffin embedded Human Kidney shows strong staining of the Brush Border in PCT. Recommended concentration, 2-3ug/ml. Western Blot: In transfected HEK293 transiently expressing human SOCS1 bands of approx. 30kDa and 25kDa are observed. These bands are not observed in the non-transfected HEK293. A similar pattern is observed in Mouse Spleen lysates. The calculated molecular size is 23.6kDa according to Human NP_003736.1 and 23.7kDa according to Mouse NP_034026.1. Recommended concentration, 1-3ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.

Epitope: C Terminus. Immunogen: Peptide with sequence C-VLRDYLSSFPFQI, from the C Terminus of the protein sequence according to NP_003736.1.

Corresponding Immunizing Peptide: Catalog #MBS425921

4507233

NP_003736.1

NM_003745.1

23,551 Da

Activated TLR4 Signalling Pathway 106400!!Adaptive Immune System Pathway 366160!!Adipogenesis Pathway 198832!!Antigen Processing: Ubiquitination Proteasome Degradation Pathway 366162!!Class I MHC Mediated Antigen Processing Presentation Pathway 366161!!Cytokine Signaling In Immune System Pathway 366171!!ECS Complex Pathway 413455!!ECS Complex Pathway 468394!!EGFR1 Signaling Pathway 198782!!EPO Receptor Signaling Pathway 198882

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]

0.1 mg

290 USD