antibody

Goat anti-TCF1/HNF1 Antibody

MBS420686

0.1 mg

225 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog

ELISA, enzyme immunoassay

Antibody

Goat anti-TCF1/HNF1 Antibody

TCF1/HNF1

Goat Anti-HNF1A Antibody; TCF1; transcription factor 1, hepatic LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor; HNF1; HNF1A; LFB1; MODY3; Interferon production regulator factor (HNF1); albumin proximal factor; hepatic nuclear factor 1; maturity onset diabetes of t; TCF1 antibody; transcription factor 1; hepatic LF-B1; hepatic nuclear factor (HNF1); albumin proximal factor antibody; HNF1 antibody; HNF1A antibody; LFB1 antibody; MODY3 antibody; Interferon production regulator factor (HNF1) antibody; albumin proximal factor antibody; hepatic nuclear factor 1 antibody; maturity onset diabetes of the young 3 antibody; transcription factor 1; hepatic antibody; TCF1 / HNF1

transcription factor 1, hepatic; Hepatocyte nuclear factor 1-alpha; hepatocyte nuclear factor 1-alpha; HNF1 homeobox A; Liver-specific transcription factor LF-B1; LFB1; Transcription factor 1; TCF-1

HNF1A

TCF1; HNF1

HNF1A; HNF1A; HNF1; LFB1; TCF1; MODY3; TCF-1; HNF-1A; IDDM20; TCF1; HNF-1-alpha; HNF-1A; LFB1; TCF-1

HNF1A_HUMAN

Polyclonal

Goat

Expected from sequence similarity: Human, Mouse, Rat, Dog

631

DELPTKKGRRNRFK

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA)

Peptide ELISA: Antibody detection limit dilution 1: 4000. Western Blot: Preliminary experiments in human liver and kidney lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).

Immunogen: Peptide with sequence C-DELPTKKGRRNRFK, from the internal region of the protein sequence according to NP_000536.3. Epitope: Internal region

38016909

NP_000536.3

NM_000545.3

12,491 Da

Adipogenesis Pathway (198832); Developmental Biology Pathway (1270302); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); IL-6 Signaling Pathway (198864); Maturity Onset Diabetes Of The Young Pathway (83096); Maturity Onset Diabetes Of The Young Pathway (508); Presenilin Action In Notch And Wnt Signaling Pathway (137914); Regulation Of Beta-cell Development Pathway (1270337); Regulation Of Gene Expression In Beta Cells Pathway (1270341); Signaling Pathways Regulating Pluripotency Of Stem Cells (1026136)

The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

HNF1A: Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'- GTTAATNATTAAC-3'. Defects in HNF1A are a cause of hepatic adenomas familial (HEPAF). Hepatic adenomas are rare benign liver tumors of presumable epithelial origin that develop in an otherwise normal liver. Hepatic adenomas may be single or multiple. They consist of sheets of well-differentiated hepatocytes that contain fat and glycogen and can produce bile. Bile ducts or portal areas are absent. Kupffer cells, if present, are reduced in number and are non-functional. Conditions associated with adenomas are insulin-dependent diabetes mellitus and glycogen storage diseases (types 1 and 3). Bi-allelic inactivation of HNF1A, whether sporadic or associated with MODY3, may be an early step in the developmant of some hepatocellular carcinomas. Defects in HNF1A are the cause of maturity-onset diabetes of the young type 3 (MODY3); also symbolized MODY-3. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Defects in HNF1A are the cause of susceptibility to diabetes mellitus insulin-dependent type 20 (IDDM20). IDDM20 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These features can result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Belongs to the HNF1 homeobox family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 12q24.2. Cellular Component: cytoplasm; nucleus; protein complex. Molecular Function: DNA binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; transcription factor activity. Biological Process: glucose homeostasis; glucose import; insulin secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter. Disease: Diabetes Mellitus, Insulin-dependent; Diabetes Mellitus, Insulin-dependent, 20; Diabetes Mellitus, Noninsulin-dependent; Hepatic Adenomas, Familial; Maturity-onset Diabetes Of The Young, Type 3; Renal Cell Carcinoma, Nonpapillary

0.1 mg

225 USD