antibody

Goat anti-AGTR1/AT1 Antibody

MBS420667

0.1 mg

300 USD

polyclonal

goat

nonconjugated

human, mouse, rat

western blot, enzyme immunoassay

Antibody

Goat anti-AGTR1/AT1 Antibody

AGTR1/AT1

AGTR1; AT1; angiotensin II receptor, type 1; AG2S; AGTR1A; AGTR1B; AT1B; AT2R1; AT2R1A; AT2R1B; HAT1R; angiotensin receptor 1; angiotensin receptor 1B; type-1B angiotensin II receptor; AGTR1 antibody; AT1 antibody; angiotensin II receptor; type 1 antibody; AG2S antibody; AGTR1A antibody; AGTR1B antibody; AT1B antibody; AT2R1 antibody; AT2R1A antibody; AT2R1B antibody; HAT1R antibody; angiotensin receptor 1 antibody; angiotensin receptor 1B antibody; type-1B angiotensin II receptor antibody; AGTR1 / AT1

type-1 angiotensin II receptor isoform 1; Type-1 angiotensin II receptor; type-1 angiotensin II receptor; angiotensin II receptor type 1; AT1AR; AT1BR; Angiotensin II type-1 receptor; AT1

AGTR1

AT1

AGTR1; AGTR1; AT1; AG2S; AT1B; AT1R; AT1AR; AT1BR; AT2R1; HAT1R; AGTR1B; AGTR1A; AGTR1B; AT2R1; AT2R1B; AT1

AGTR1_HUMAN

Polyclonal

Goat

Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat

359

EIQKNKPRNDDIFK

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 38kDa band observed in Liver lysates of Human, Mouse and Rat (calculated MW of 41.1kDa according to NP_000676.1, NP_004826.2, NP_033611.1, NP_114038.1 and NP_114438.1). Recommended concentration: 0.3-1ug/ml.

Immunogen: Peptide with sequence C-EIQKNKPRNDDIFK, from the internal region of the protein sequence according to NP_000676.1; NP_004826.2; NP_033611.1; NP_114038.1; NP_114438.1. Epitope: Internal region

Note: All reported variants represent identical protein (NP_000676.1, NP_004826.2, NP_033611.1, NP_114038.1 and NP_114438.1).

4501997

NP_000676.1

NM_000685.4

41,061 Da

ACE Inhibitor Pathway (198763); AGE-RAGE Signaling Pathway In Diabetic Complications (1319988); AGE-RAGE Signaling Pathway In Diabetic Complications (1319775); Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Aldosterone Synthesis And Secretion Pathway (1272485); Aldosterone Synthesis And Secretion Pathway (1285075); Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Arf6 Signaling Events Pathway (138034); Calcium Signaling Pathway (83050)

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]

AT1: receptor for angiotensin II. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. Mediates the major cardiovascular effects of angiotensin II. May play role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1. Chromosomal Location of Human Ortholog: 3q24. Cellular Component: integral to membrane; integral to plasma membrane; intracellular; plasma membrane. Molecular Function: angiotensin type I receptor activity; angiotensin type II receptor activity; bradykinin receptor binding; protein binding; protein heterodimerization activity. Biological Process: calcium-mediated signaling; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); kidney development; positive regulation of cellular protein metabolic process; positive regulation of inflammatory response; positive regulation of NAD(P)H oxidase activity; positive regulation of phospholipase A2 activity; regulation of cell growth; regulation of cell proliferation; regulation of inflammatory response; regulation of systemic arterial blood pressure by renin-angiotensin; regulation of vasoconstriction; regulation of vasodilation; renin-angiotensin regulation of aldosterone production; renin-angiotensin regulation of blood vessel size; Rho protein signal transduction. Disease: Hypertension, Essential; Renal Tubular Dysgenesis

0.1 mg

300 USD