catalog number :
MBS420659
products full name :
Goat anti-DOCK1 Antibody
products short name :
DOCK1
products name syn :
DOCK1; DOCK180; dedicator of cyto-kinesis 1; RP11-82L9.1; ced5; DOCK1; DOCK180; dedicator of cyto-kinesis 1; RP11-82L9.1; ced5
other names :
dedicator of cytokinesis protein 1 isoform 2; Dedicator of cytokinesis protein 1; dedicator of cytokinesis protein 1; DOwnstream of CrK; 180 kDa protein downstream of CRK; dedicator of cytokinesis 1; 180 kDa protein downstream of CRK; DOCK180
products gene name :
DOCK1
other gene names :
DOCK1; DOCK1; ced5; DOCK180; DOCK180
uniprot entry name :
DOCK1_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Pig, Cow
sequence :
TTRKQTSVDSGIVQ
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Western Blot (WB)
app notes :
Western Blot: Approx 150-200kDa band seen in A431 cell lysate. Recommended for use at 3-4ug/ml.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence C-TTRKQTSVDSGIVQ, from the C Terminus of the protein sequence according to NP_001371.1.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS425468
ncbi acc num :
NP_001371.1
ncbi gb acc num :
NM_001380.4
ncbi mol weight :
215,346 Da
ncbi pathways :
Axon Guidance Pathway 105688!!Bacterial Invasion Of Epithelial Cells Pathway 149807!!Bacterial Invasion Of Epithelial Cells Pathway 148661!!DCC Mediated Attractive Signaling Pathway 161000!!Developmental Biology Pathway 477129!!Factors Involved In Megakaryocyte Development And Platelet Production Pathway 187196!!Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway 771577!!Focal Adhesion Pathway 198795!!Focal Adhesion Pathway 83067!!Focal Adhesion Pathway 478
ncbi summary :
This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]