antibody

Goat anti-Uncoupling protein 2 / UCP2 Antibody

MBS420657

0.1 mg

290 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog

western blot, enzyme immunoassay

Antibody

Goat anti-Uncoupling protein 2 / UCP2 Antibody

Uncoupling protein 2/UCP2

UCP2; uncoupling protein 2 (mitochondrial; proton carrier); SLC25A8; UCPH; uncoupling protein 2; uncoupling protein-2; UCP2; uncoupling protein 2 (mitochondrial, proton carrier); SLC25A8; UCPH; uncoupling protein 2; uncoupling protein-2

mitochondrial uncoupling protein 2; Mitochondrial uncoupling protein 2; mitochondrial uncoupling protein 2; solute carrier family 25 member 8; uncoupling protein 2 (mitochondrial, proton carrier); Solute carrier family 25 member 8; UCPH

UCP2

UCP2; UCP2; UCPH; BMIQ4; SLC25A8; SLC25A8; UCP 2

UCP2_HUMAN

Polyclonal

Goat

Human, Mouse, Rat, Dog

309

DSVKQFYTKGSEH

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Western Blot: Approx 36kDa band observed in Human Liver lysates (calculated MW of 33.2kDa according to NP_003346.2). Recommended concentration: 0.05-0.1ug/ml. Peptide ELISA: antibody detection limit dilution 1:64000.

Epitope: Internal Region. Immunogen: Peptide with sequence C-DSVKQFYTKGSEH, from the internal region of the protein sequence according to NP_003346.2.

Corresponding Immunizing Peptide: Catalog #MBS425926

13259541

NP_003346.2

NM_003355.2

33,229 Da

Electron Transport Chain Pathway 198860!!Energy Metabolism Pathway 198907!!FOXA2 And FOXA3 Transcription Factor Networks Pathway 137911!!Metabolism Pathway 477135!!Mitochondrial Uncoupling Proteins Pathway 160963!!Respiratory Electron Transport, ATP Synthesis By Chemiosmotic Coupling, And Heat Production By Uncoupling Proteins. Pathway 105921!!The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway 477137!!The Fatty Acid Cycling Model Pathway 160964!!The Proton Buffering Model Pathway 160965

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]

0.1 mg

290 USD