catalog number :
MBS420639
products full name :
Goat anti-DUSP10 / MKP5 Antibody
products short name :
DUSP10/MKP5
products name syn :
DUSP10; MKP5; dual specificity phosphatase 10; MKP-5; dual specificity phosphatase MKP-5; serine/threonine specific protein phosphatase; DUSP10; MKP5; dual specificity phosphatase 10; MKP-5; dual specificity phosphatase MKP-5; serine/threonine specific protein phosphatase
other names :
dual specificity protein phosphatase 10; Dual specificity protein phosphatase 10; dual specificity protein phosphatase 10; map kinase phosphatase 5; dual specificity phosphatase MKP-5; serine/threonine specific protein phosphatase; mitogen-activated protein kinase phosphatase 5; dual specificity phosphatase 10; Mitogen-activated protein kinase phosphatase 5; MAP kinase phosphatase 5; MKP-5
products gene name :
DUSP10
other gene names :
DUSP10; DUSP10; MKP5; MKP-5; MKP5; MAP kinase phosphatase 5; MKP-5
uniprot entry name :
DUS10_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Cow
sequence :
CRILTPKLMGVETVV
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 53kDa band seen in Human Liver lysate. Recommended for use at 0.5-2ug/ml. Peptide ELISA: antibody detection limit dilution 1:8000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence CRILTPKLMGVETVV, from the C Terminus of the protein sequence according to NP_009138.1; NP_653329.1; NP_653330.1. Corresponding Immunizing Peptide: Catalog #MBS425571
other info2 :
Important Note: This antibody is expected to recognise both reported Human isofoms. The variants NP_653329.1 and NP_653330.1 represent identical protein.
ncbi acc num :
NP_009138.1
ncbi gb acc num :
NM_007207.5
ncbi mol weight :
16,110 Da
ncbi pathways :
ATF-2 Transcription Factor Network Pathway 138006!!MAPK Signaling Pathway 198779!!MAPK Signaling Pathway 83048!!MAPK Signaling Pathway 456!!Regulation Of P38-alpha And P38-beta Pathway 137964
ncbi summary :
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]