catalog number :
MBS420631
products full name :
Goat anti-EDD1 / HYD Antibody
products short name :
EDD1/HYD
products name syn :
UBR5; EDD1; E3 ubiquitin protein ligase; HECT domain containing; 1; DD5; EDD; HYD; KIAA0896; progestin induced protein; ubiquitin-protein ligase; E3 identified by differential display; hyperplastic discs protein homolog; ubiquitin protein ligase E3 component n-recognin 5; FLJ11310; MGC57263; UBR5; EDD1; E3 ubiquitin protein ligase, HECT domain containing, 1; DD5; EDD; HYD; KIAA0896; progestin induced protein; ubiquitin-protein ligase; E3 identified by differential display; hyperplastic discs protein homolog; ubiquitin protein ligase E3 component n-recognin 5; FLJ11310; MGC57263
other names :
E3 ubiquitin-protein ligase UBR5 isoform 1; E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase UBR5; progestin induced protein; progestin-induced protein; hyperplastic discs protein homolog; E3 identified by differential display; E3 ubiquitin-protein ligase, HECT domain-containing 1; E3 ubiquitin protein ligase, HECT domain containing, 1; ubiquitin protein ligase E3 component n-recognin 5; E3 ubiquitin-protein ligase, HECT domain-containing 1; Hyperplastic discs protein homolog; hHYD; Progestin-induced protein
products gene name :
UBR5
other gene names :
UBR5; UBR5; DD5; EDD; HYD; EDD1; EDD; EDD1; HYD; KIAA0896; hHYD
uniprot entry name :
UBR5_HUMAN
reactivity :
Human, Mouse, Rat, Pig, Cow, Rabbit
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Immunohistochemistry: In paraffin embedded Human Testis shows nuclear staining in all germ cells. Recommended concentration, 1-2ug/ml. Western Blot: An anonymous customer found positive results in WB on Human breast cancer cells (MDA-MB-468). An anonymous customer found positive results in WB on Human HeLa cells. An anonymous customer found positive results in WB on Human glioblastoma (T98G cells). An anonymous customer found positive results in WB on Rat glioma (C6 cells). An anonymous customer found positive results in WB on Mouse fibroblasts (NIH 3T3). An anonymous customer found positive results in WB on Rabbit heart tissue. Peptide ELISA: antibody detection limit dilution 1:4000. Immunoprecipitation: An anonymous customer found positive results in IP on Human breast cancer cells. IP; An anonymous customer found positive results in IP on Mouse lung tissue. IP; An anonymous customer found positive results in IP on Rat lung tissue. IP; An anonymous customer found positive results in IP on Rabbit heart tissue.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence C-LAIKTKNFGFV, from the C Terminus of the protein sequence according to NP_056986.2.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS426448
ncbi acc num :
NP_056986.2
ncbi gb acc num :
NM_015902.5
ncbi mol weight :
309,224 Da
ncbi pathways :
Tryptophan Metabolism Pathway 198850!!Ubiquitin Mediated Proteolysis Pathway 83056!!Ubiquitin Mediated Proteolysis Pathway 466
ncbi summary :
This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]