Goat anti-TCF2/VHNF1 Antibody | MyBioSource MBS420628 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-TCF2/VHNF1 Antibody

catalog :

MBS420628

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow, zebrafish

application :

western blot, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420628

products type :

Antibody

products full name :

Goat anti-TCF2/VHNF1 Antibody

products short name :

TCF2/VHNF1

products name syn :

TCF2; VHNF1; transcription factor 2, hepatic LF-B3 variant hepatic nuclear factor; FJHN; HNF1B; HNF1beta; HNF2; LFB3; MODY5; transcription factor 2; TCF2 antibody; VHNF1 antibody; transcription factor 2; hepatic LF-B3 variant hepatic nuclear factor antibody; FJHN antibody; HNF1B antibody; HNF1beta antibody; HNF2 antibody; LFB3 antibody; MODY5 antibody; transcription factor 2 antibody; TCF2 / VHNF1

other names :

hepatocyte nuclear factor 1-beta isoform 1; Hepatocyte nuclear factor 1-beta; hepatocyte nuclear factor 1-beta; HNF1 homeobox B; Homeoprotein LFB3; Transcription factor 2; TCF-2; Variant hepatic nuclear factor 1; vHNF1

products gene name :

HNF1B

products gene name syn :

TCF2; VHNF1

other gene names :

HNF1B; HNF1B; FJHN; HNF2; LFB3; TCF2; HPC11; LF-B3; MODY5; TCF-2; VHNF1; HNF-1B; HNF1beta; HNF-1-beta; TCF2; HNF-1-beta; HNF-1B; TCF-2; vHNF1

uniprot entry name :

HNF1B_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow, Zebrafish

sequence length :

557

sequence :

QAYDRQKNPSKEER

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 64000. Immunocytochemistry: An anonymous customer found positive results in ICC on Human primitive gut tube from human embryonic stem cells.

other info1 :

Immunogen: Peptide with sequence C-QAYDRQKNPSKEER, from the internal region of the protein sequence according to NP_000449.1; NP_001159395.1. Epitope: Internal region

other info2 :

Note: This antibody is expected to recognize both reported isoforms (NP_000449.1; NP_001159395.1). This product may cross-react with HNF1A.

ncbi gi num :

4507397

ncbi acc num :

NP_000449.1

ncbi gb acc num :

NM_000458.3

ncbi mol weight :

46,907 Da

ncbi pathways :

Developmental Biology Pathway (1270302); Maturity Onset Diabetes Of The Young Pathway (83096); Maturity Onset Diabetes Of The Young Pathway (508); Regulation Of Beta-cell Development Pathway (1270337); Regulation Of Gene Expression In Early Pancreatic Precursor Cells Pathway (1270338); Regulation Of Gene Expression In Late Stage (branching Morphogenesis) Pancreatic Bud Precursor Cells Pathway (1270339)

ncbi summary :

This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

uniprot summary :

TCF2: Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in HNF1B are the cause of renal cysts and diabetes syndrome (RCAD); also called maturity-onset diabetes of the young type 5 (MODY5) or familial hypoplastic glomerulocystic kidney disease (GCKD). RCAD is an autosomal dominant disorder comprising non-diabetic renal disease resulting from abnormal renal development, and diabetes, which in some cases occurs earlier than age 25 years and is thus consistent with a diagnosis of maturity-onset diabetes of the young (MODY5). The renal disease is highly variable and includes renal cysts, glomerular tufts, aberrant nephrogenesis, primitive tubules, irregular collecting systems, oligomeganephronia, enlarged renal pelves, abnormal calyces, small kidney, single kidney, horseshoe kidney, and hyperuricemic nephropathy. Defects in HNF1B may be rare genetic risk factor contributing to the development of non-insulin-dependent diabetes mellitus (NIDDM). NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance. Defects in HNF1B may be a cause of susceptibility to prostate cancer hereditary type 11 (HPC11). It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Belongs to the HNF1 homeobox family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 17q12. Cellular Component: nucleoplasm; nucleus; transcription factor complex. Molecular Function: DNA binding; protein binding; protein complex binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription factor activity. Biological Process: anterior/posterior pattern formation; branching morphogenesis of a tube; circadian regulation of gene expression; embryonic digestive tract morphogenesis; endocrine pancreas development; endodermal cell fate specification; epithelial cell proliferation; genitalia development; hindbrain development; inner cell mass cell differentiation; insulin secretion; kidney development; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; positive regulation of transcription, DNA-dependent; pronephros development; protein-DNA complex assembly; regulation of endodermal cell fate specification; regulation of Wnt receptor signaling pathway; response to drug; response to glucose stimulus; response to organic cyclic substance; transcription, DNA-dependent. Disease: Diabetes Mellitus, Noninsulin-dependent; Renal Cell Carcinoma, Nonpapillary; Renal Cysts And Diabetes Syndrome

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage