Goat anti-ADRB1 Antibody | MyBioSource MBS420627 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-ADRB1 Antibody

catalog :

MBS420627

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420627

products type :

Antibody

products full name :

Goat anti-ADRB1 Antibody

products short name :

ADRB1

products name syn :

ADRB1; adrenergic, beta-1-, receptor; ADRB1R; B1AR; BETA1AR; RHR; beta-1-adrenergic receptor; ADRB1 antibody; adrenergic; beta-1-; receptor antibody; ADRB1R antibody; B1AR antibody; BETA1AR antibody; RHR antibody; beta-1-adrenergic receptor antibody

other names :

beta-1 adrenergic receptor; Beta-1 adrenergic receptor; beta-1 adrenergic receptor; adrenoceptor beta 1; Beta-1 adrenoreceptor; Beta-1 adrenoceptor

products gene name :

ADRB1

other gene names :

ADRB1; ADRB1; RHR; B1AR; ADRB1R; BETA1AR; ADRB1R; B1AR; Beta-1 adrenoceptor

uniprot entry name :

ADRB1_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog

sequence length :

477

sequence :

ESDEARRCYNDPK

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 1000. Western Blot: Approx 50kDa band observed in Human Heart lysates (calculated MW of 51.2kDa according to NP_000675.1). Recommended concentration: 2-6. 0ug/ml.

other info1 :

Immunogen: Peptide with sequence ESDEARRCYNDPK, from the internal region of the protein sequence according to NP_000675.1. Epitope: Internal region

ncbi gi num :

4557265

ncbi acc num :

NP_000675.1

ncbi gb acc num :

NM_000684.2

ncbi mol weight :

51,323 Da

ncbi pathways :

Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Adrenoceptors Pathway (1269555); Amine Ligand-binding Receptors Pathway (1269553); Calcium Regulation In The Cardiac Cell Pathway (198906); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285)

ncbi summary :

The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008]

uniprot summary :

ADRB1: a GPCR-coupled 7 transmembrane receptor that binds epinephrine and norepinephrine with approximately equal affinity. Mediates the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Interacts with PIST and PSD-95. Localized at the plasma membrane and in the Golgi upon PIST overexpression. Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase. Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1. Chromosomal Location of Human Ortholog: 10q25.3. Cellular Component: early endosome; integral to plasma membrane; plasma membrane. Molecular Function: alpha-2A adrenergic receptor binding; beta-adrenergic receptor activity; beta1-adrenergic receptor activity; epinephrine binding; norepinephrine binding; PDZ domain binding; protein binding; protein heterodimerization activity; Ras guanyl-nucleotide exchange factor activity; receptor signaling protein activity. Biological Process: adenylate cyclase activation; brown fat cell differentiation; cell-cell signaling; diet induced thermogenesis; fear response; heat generation; negative regulation of multicellular organism growth; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure; positive regulation of cAMP biosynthetic process; positive regulation of GTPase activity; positive regulation of heart rate by epinephrine-norepinephrine; positive regulation of the force of heart contraction by epinephrine-norepinephrine; response to cold; thermoregulation. Disease: Resting Heart Rate, Variation In

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage