catalog number :
MBS420621
products full name :
Goat anti-TRAP2 / Proteasome subunit 26S Antibody
products short name :
TRAP2/Proteasome subunit 26S
products name syn :
TRAP2; MGC14274; PSMD2; S2; P97; proteasome (prosome; macropain) 26S subunit; non-ATPase; 2; 55.11 protein; TNFR-associated protein 2; 26S proteasome subunit p97; 26S proteasome regulatory subunit S2; 26S proteasome non-ATPase regulatory subunit 2; tumor necrosis factor receptor-associated protein 2; PSMD2; TRAP2; MGC14274; S2; P97; proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; 55.11 protein; TNFR-associated protein 2; 26S proteasome subunit p97; 26S proteasome regulatory subunit S2; 26S proteasome non-ATPase regulatory subunit 2; tumor necrosis factor receptor-associated protein 2; Rpn1; proteasome 26S non-ATPase subunit 2
other names :
26S proteasome non-ATPase regulatory subunit 2 isoform 1; 26S proteasome non-ATPase regulatory subunit 2; 26S proteasome non-ATPase regulatory subunit 2; 55.11 protein; protein 55.11; TNFR-associated protein 2; tumor necrosis factor type 1 receptor-associated protein 2; proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; 26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; Protein 55.11; Tumor necrosis factor type 1 receptor-associated protein 2
products gene name :
PSMD2
other gene names :
PSMD2; PSMD2; S2; P97; RPN1; TRAP2; TRAP2
uniprot entry name :
PSMD2_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 100kDa band observed in Human epidermoid carcinoma A431 lysates (calculated MW of 100kDa according to NP_002799). Recommended concentration: 0.03-0.3ug/ml. Peptide ELISA: antibody detection limit dilution 1:16000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence C-VILRKNPNYDL, from the C Terminus of the protein sequence according to NP_002799.3.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS425622
ncbi acc num :
NP_002799.3
ncbi gb acc num :
NM_002808.4
ncbi mol weight :
85,606 Da
ncbi pathways :
AMER1 Mutants Destabilize The Destruction Complex Pathway 1016198!!APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway 1016193!!APC Truncation Mutants Have Impaired AXIN Binding Pathway 1016194!!APC/C-mediated Degradation Of Cell Cycle Proteins Pathway 105825!!APC/C:Cdc20 Mediated Degradation Of Securin Pathway 105833!!APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway 105831!!APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway 105835!!AUF1 (hnRNP D0) Destabilizes MRNA Pathway 187212!!AXIN Missense Mutants Destabilize The Destruction Complex Pathway 1016197!!AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway 1016195
ncbi summary :
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]