Goat anti-FGF23 Antibody | MyBioSource MBS420602 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-FGF23 Antibody

catalog :

MBS420602

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420602

products type :

Antibody

products full name :

Goat anti-FGF23 Antibody

products short name :

FGF23

products name syn :

FGF23; fibroblast growth factor 23; ADHR; HPDR2; HYPF; PHPTC; tumor-derived hypophosphatemia inducing factor; FGF23 antibody; fibroblast growth factor 23 antibody; ADHR antibody; HPDR2 antibody; HYPF antibody; PHPTC antibody; tumor-derived hypophosphatemia inducing factor antibody

other names :

fibroblast growth factor 23; Fibroblast growth factor 23; fibroblast growth factor 23; fibroblast growth factor 23; Phosphatonin; Tumor-derived hypophosphatemia-inducing factor

products gene name :

FGF23

other gene names :

FGF23; FGF23; ADHR; FGFN; HYPF; HPDR2; PHPTC; HYPF; FGF-23

uniprot entry name :

FGF23_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human

sequence length :

251

sequence :

RHTRSAEDDSERD

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Approx 28+37kDa bands observed in Human Brain (Hippocampus) lysates (calculated MW of 27.9kDa according to NP_065689.1). The observed molecular weights correspond to earlier findings in literature with different antibodies (Garringer et al, Am J Physiol Endocrinol Metab.2008 Oct;295(4): E929-37. PMID: 18682534). Recommended concentration: 0.3-1. 0ug/ml.

other info1 :

Immunogen: Peptide with sequence C-RHTRSAEDDSERD, from the internal region of the protein sequence according to NP_065689.1. Epitope: Internal region

ncbi gi num :

10190674

ncbi acc num :

NP_065689.1

ncbi gb acc num :

NM_020638.2

ncbi mol weight :

27,954 Da

ncbi pathways :

ARMS-mediated Activation Pathway (1269471); Activated Point Mutants Of FGFR2 Pathway (1268871); Adaptive Immune System Pathway (1269171); Axon Guidance Pathway (1270303); Constitutive Signaling By Aberrant PI3K In Cancer Pathway (1268880); Cytokine Signaling In Immune System Pathway (1269310); DAP12 Interactions Pathway (1269283); DAP12 Signaling Pathway (1269284); Developmental Biology Pathway (1270302); Disease Pathway (1268854)

ncbi summary :

This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013]

uniprot summary :

FGF23: Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL. Acts directly on the parathyroid to decrease PTH secretion. Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR). ADHR is characterized by low serum phosphorus concentrations, rickets, osteomalacia, leg deformities, short stature, bone pain and dental abscesses. Defects in FGF23 are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC). HFTC is a severe autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Belongs to the heparin-binding growth factors family. Protein type: Secreted; Secreted, signal peptide; Cytokine. Chromosomal Location of Human Ortholog: 12p13.3. Cellular Component: extracellular region; extracellular space; Golgi lumen. Molecular Function: 1-phosphatidylinositol-3-kinase activity; growth factor activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; type 1 fibroblast growth factor receptor binding. Biological Process: cell differentiation; cellular phosphate ion homeostasis; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; negative regulation of bone mineralization; negative regulation of hormone secretion; negative regulation of osteoblast differentiation; peptidyl-tyrosine phosphorylation; phosphate ion homeostasis; phosphoinositide phosphorylation; phosphoinositide-mediated signaling; positive regulation of GTPase activity; positive regulation of transcription, DNA-dependent; regulation of phosphoinositide 3-kinase cascade; response to magnesium ion; vitamin D catabolic process. Disease: Hypophosphatemic Rickets, Autosomal Dominant

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage