catalog number :
MBS420578
products full name :
Goat anti-GRAF / ARHGAP26 Antibody
products short name :
GRAF/ARHGAP26
products name syn :
ARHGAP26; GRAF; Rho GTPase activating protein 26; KIAA0621; FLJ42530; OPHN1L; OPHN1L1; GTPase regulator associated with FAK; GTPase regulator associated with focal adhesion kinase pp125(FAK); GTPase regulator associated with the focal adhesion kinase pp125; GRAF; Rho GTPase activating protein 26; KIAA0621; FLJ42530; OPHN1L; OPHN1L1; GTPase regulator associated with FAK; GTPase regulator associated with focal adhesion kinase pp125(FAK); GTPase regulator associated with the focal adhesion kinase pp125
other names :
rho GTPase-activating protein 26 isoform a; Rho GTPase-activating protein 26; rho GTPase-activating protein 26; oligophrenin-1-like protein; GTPase regulator associated with focal adhesion kinase pp125(FAK); Rho GTPase activating protein 26; GTPase regulator associated with focal adhesion kinase; Oligophrenin-1-like protein; Rho-type GTPase-activating protein 26
products gene name :
ARHGAP26
other gene names :
ARHGAP26; ARHGAP26; GRAF; GRAF1; OPHN1L; OPHN1L1; GRAF; KIAA0621; OPHN1L
uniprot entry name :
RHG26_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 90kDa band observed in Human Heart lysates (calculated MW of 92.2kDa according to NP_055886.1). Recommended concentration: 0.3-1ug/ml. An additional strong band of unknown identity was also consistently observed at 16kDa. This band was successfully blocked by incubation with the immunising peptide. Peptide ELISA: antibody detection limit dilution 1:64000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence C-KTGLIPENYVEFL, from the C Terminus of the protein sequence according to NP_055886.1; NP_001129080.1. Corresponding Immunizing Peptide: Catalog #MBS425474
other info2 :
Important Note: This antibody is expected to recognise both reported isoforms.
ncbi acc num :
NP_055886.1
ncbi gb acc num :
NM_015071.4
ncbi mol weight :
86,165 Da
ncbi pathways :
Rho GTPase Cycle Pathway 106503!!Signal Transduction Pathway 477114!!Signaling By Rho GTPases Pathway 106502!!Signaling Events Mediated By Focal Adhesion Kinase Pathway 169348
ncbi summary :
Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]