catalog number :
MBS420574
products full name :
Goat anti-RXR alpha Antibody
products short name :
RXR alpha
products name syn :
RXRA; NR2B1; retinoid X receptor, alpha; FLJ16020; FLJ16733; MGC102720; FLJ00280; FLJ00318; RXRA antibody; NR2B1 antibody; retinoid X receptor; alpha antibody; FLJ16020 antibody; FLJ16733 antibody; MGC102720 antibody; FLJ00280 antibody; FLJ00318 antibody; RXR alpha
other names :
retinoic acid receptor RXR-alpha isoform a; Retinoic acid receptor RXR-alpha; retinoic acid receptor RXR-alpha; retinoid X receptor alpha; Nuclear receptor subfamily 2 group B member 1; Retinoid X receptor alpha
products gene name :
RXRA
products gene name syn :
RXR alpha
other gene names :
RXRA; RXRA; NR2B1; NR2B1
uniprot entry name :
RXRA_HUMAN
reactivity :
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat
sequence :
CQVNSSLTSPTGRGSM
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 60kDa band observed in nuclear lysates of cell line HeLa (calculated MW of 50.8kDa according to NP_002948.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Solomon et al, J Biol Chem.1998 Jul 10;273(28): 17573-8; PMID: 9651351. Recommended concentration: 0.3-1ug/ml.
other info1 :
Immunogen: Peptide with sequence CQVNSSLTSPTGRGSM, from the internal region of the protein sequence according to NP_002948.1. Epitope: Internal region
other info2 :
Note: This antibody is expected to recognise an epitope corresponding to aa 14-28 of human RXR alpha protein and does not cross-react with either RXR beta or gamma.
ncbi acc num :
NP_002948.1
ncbi gb acc num :
NM_002957.5
ncbi mol weight :
41,060 Da
ncbi pathways :
Activation Of HOX Genes During Differentiation Pathway (1339139); Activation Of Anterior HOX Genes In Hindbrain Development During Early Embryogenesis Pathway (1339140); Activation Of Gene Expression By SREBF (SREBP) Pathway (1270039); Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Adipogenesis Pathway (198832); BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway (1269872); Bile Acid And Bile Salt Metabolism Pathway (1270040); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095)
ncbi summary :
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]