catalog number :
MBS420573
products full name :
Goat anti-MLL4 Antibody
products short name :
MLL4
products name syn :
MLL4; myeloid/lymphoid or mixed-lineage leukemia 4; HRX2; MLL2; KIAA0304; KIAA0304 gene product; MLL4; myeloid/lymphoid or mixed-lineage leukemia 4; HRX2; MLL2; KIAA0304; KIAA0304 gene product
other names :
histone-lysine N-methyltransferase 2B; Histone-lysine N-methyltransferase 2B; histone-lysine N-methyltransferase 2B; trithorax homologue 2; WW domain binding protein 7; mixed lineage leukemia gene homolog 2; histone-lysine N-methyltransferase MLL4; myeloid/lymphoid or mixed-lineage leukemia protein 4; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 4; lysine (K)-specific methyltransferase 2B; Myeloid/lymphoid or mixed-lineage leukemia protein 4; Trithorax homolog 2; WW domain-binding protein 7; WBP-7
products gene name :
MLL4
other gene names :
KMT2B; KMT2B; HRX2; MLL2; MLL4; TRX2; WBP7; MLL1B; WBP-7; HRX2; KIAA0304; MLL2; MLL4; TRX2; WBP7; Lysine N-methyltransferase 2B; WBP-7
uniprot entry name :
KMT2B_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Pig
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
app notes :
Immunohistochemistry: In paraffin embedded Human Testis shows cytoplasm staining of spermatids. Recommended concentration, 5-10ug/ml. Western Blot: Preliminary experiments gave no signal but low background in Human Heart lysates at up to 1ug/ml. However this used our routine western blotting protocol which we would not expect to reliably detect proteins as large as the predicted size of approx. 312KDa according to NP_055542. Peptide ELISA: antibody detection limit dilution 1:128000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence CNCGAKRCRRFLN, from the C Terminus of the protein sequence according to NP_055542.1.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS425982
ncbi acc num :
NP_055542.1
ncbi gb acc num :
NM_014727.2
ncbi mol weight :
61,562 Da
ncbi pathways :
Lysine Degradation Pathway 82956!!Lysine Degradation Pathway 320
ncbi summary :
This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. [provided by RefSeq, Jul 2008]