catalog number :
MBS420568
products full name :
Goat anti-Npy2r (mouse) Antibody
products short name :
Npy2r
products name syn :
Npy2r; neuropeptide Y receptor Y2; MGC124241; MGC124242; MGC124244; NPY-Y2 receptor; Npy2r antibody; neuropeptide Y receptor Y2 antibody; MGC124241 antibody; MGC124242 antibody; MGC124244 antibody; NPY-Y2 receptor antibody; Npy2r (mouse)
other names :
neuropeptide Y receptor Y2; Neuropeptide Y receptor type 2; neuropeptide Y receptor type 2; neuropeptide Y receptor Y2; NPY-Y2 receptor; Y2 receptor
products gene name :
Npy2r
other gene names :
Npy2r; Npy2r; NPY2-R; NPY2-R; Y2 receptor
uniprot entry name :
NPY2R_MOUSE
reactivity :
Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 40+45kDa bands observed in Mouse Brain and Rat Brain lysates (calculated MW of 42.6kDa according to NP032757.1). Recommended concentration: 0.1-0.3ug/ml. Immunoprecipitation: A customer successfully used this product for IP of Human Y2R, but the Human Y2R could not be detected in WB by this antibody.
other info1 :
Immunogen: Peptide with sequence C-KAKKNLEVKKNN, from the internal region of the protein sequence according to NP_032757.1. Epitope: Internal region
other info2 :
Note: Pease note this antibody was designed using the Mouse sequence NP_032757.1, which differs by 1 amino acid from the Human sequence NP_000901.1.
ncbi acc num :
NP_032757.1
ncbi gb acc num :
NM_008731.2
ncbi mol weight :
42,628 Da
ncbi pathways :
Class A/1 (Rhodopsin-like Receptors) Pathway (1367055); G Alpha (i) Signalling Events Pathway (1367086); GPCR Downstream Signaling Pathway (1367084); GPCR Ligand Binding Pathway (1367054); GPCRs, Class A Rhodopsin-like Pathway (198308); Neuroactive Ligand-receptor Interaction Pathway (83250); Neuroactive Ligand-receptor Interaction Pathway (462); Non-odorant GPCRs Pathway (198395); Peptide GPCRs Pathway (198352); Peptide Ligand-binding Receptors Pathway (1367056)
uniprot summary :
NPY2R: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY NPY PYY (3-36) NPY (2-36) [Ile-31, Gln-34] PP [Leu- 31, Pro-34] NPY PP, [Pro-34] PYY and NPY free acid. Belongs to the G-protein coupled receptor 1 family. Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral. Cellular Component: cytosol; integral to membrane; integral to plasma membrane; membrane; nonmotile primary cilium; plasma membrane. Molecular Function: G-protein coupled receptor activity; neuropeptide Y receptor activity; peptide YY receptor activity; signal transducer activity. Biological Process: behavioral fear response; cell surface receptor linked signal transduction; elevation of cytosolic calcium ion concentration; feeding behavior; G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; negative regulation of cAMP biosynthetic process; negative regulation of neurological process; negative regulation of secretion; negative regulation of synaptic transmission; negative regulation of synaptic transmission, glutamatergic; nitric oxide mediated signal transduction; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of dopamine secretion; positive regulation of peptide secretion; positive regulation of smooth muscle contraction; regulation of sensory perception of pain; secretion; signal transduction; synaptic transmission