Goat anti-Nucleophosmin/NPM1 Antibody | MyBioSource MBS420563 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-Nucleophosmin/NPM1 Antibody

catalog :

MBS420563

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420563

products type :

Antibody

products full name :

Goat anti-Nucleophosmin/NPM1 Antibody

products short name :

Nucleophosmin/NPM1

products name syn :

NPM1; NPM; B23; nucleophosmin (nucleolar phosphoprotein B23, numatrin); numatrin; nucleolar phosphoprotein B23; nucleophosmin/nucleoplasmin family, member 1; MGC104254; nucleophosmin 1; NPM1 antibody; NPM antibody; B23 antibody; nucleophosmin (nucleolar phosphoprotein B23; numatrin) antibody; numatrin antibody; nucleolar phosphoprotein B23 antibody; nucleophosmin/nucleoplasmin family; member 1 antibody; MGC104254 antibody; nucleophosmin 1 antibody; Nucleophosmin; Nucleophosmin / NPM1

other names :

nucleophosmin isoform 1; Nucleophosmin; nucleophosmin; nucleophosmin (nucleolar phosphoprotein B23, numatrin); Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin

products gene name :

NPM1

other gene names :

NPM1; NPM1; B23; NPM; NPM; NPM

uniprot entry name :

NPM_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow

sequence length :

294

sequence :

QEAIQDLWQWRKSL

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 8000. Western Blot: Approx 37kDa band observed in lysates of cell lijnes HeLa and NIH3T3 and in Mouse and Rat Spleen lysates (calculated MW of 32.6kDa according to NP_002511.1). Recommended concentration: 0. 03-0.1ug/ml.

other info1 :

Immunogen: Peptide with sequence C-QEAIQDLWQWRKSL, from the C Terminus of the protein sequence according to NP_002511.1; NP_954654.1. Epitope: C Terminus

other info2 :

Note: This antibody is expected to recognise both report isoforms (NP_002511.1; NP_954654.1).

ncbi gi num :

10835063

ncbi acc num :

NP_002511.1

ncbi gb acc num :

NM_002520.6

ncbi mol weight :

28,400 Da

ncbi pathways :

Aurora B Signaling Pathway (138080); BARD1 Signaling Events Pathway (137959); Cell Cycle Pathway (1269741); Chromosome Maintenance Pathway (1269853); Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway (1269855); Disease Pathway (1268854); Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650); HIF-1-alpha Transcription Factor Network Pathway (138045); HIV Infection Pathway (1269057)

ncbi summary :

This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]

uniprot summary :

NPM1: a nucleolar protein associated with nucleolar ribonucleoprotein structures and that binds single-stranded nucleic acids. Is a major component of template activating factor (TAF)-III. It plays a role in controlling centrosome duplication, and may function in the assembly and/or transport of the ribosome. Two alternatively spliced isoforms have been described. Protein type: Nucleolus; Translation; RNA-binding; Oncoprotein. Chromosomal Location of Human Ortholog: 5q35.1. Cellular Component: centrosome; cytoplasm; cytosol; focal adhesion; membrane; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex; spindle pole centrosome. Molecular Function: histone binding; NF-kappaB binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; protein kinase inhibitor activity; ribosomal large subunit binding; ribosomal small subunit binding; RNA binding; Tat protein binding; transcription coactivator activity; unfolded protein binding. Biological Process: activation of NF-kappaB transcription factor; cell aging; centrosome cycle; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA repair; DNA replication-independent nucleosome assembly at centromere; intracellular protein transport; negative regulation of apoptosis; negative regulation of cell proliferation; nucleocytoplasmic transport; nucleosome assembly; positive regulation of cell proliferation; positive regulation of transcription, DNA-dependent; positive regulation of translation; protein localization; protein oligomerization; regulation of centriole replication; regulation of endodeoxyribonuclease activity; response to stress; ribosome assembly; signal transduction; viral reproduction

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage