Goat anti-CYP3A4 Antibody | MyBioSource MBS420553 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-CYP3A4 Antibody

catalog :

MBS420553

quantity :

0.1 mg

price :

225 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420553

products type :

Antibody

products full name :

Goat anti-CYP3A4 Antibody

products short name :

CYP3A4

products name syn :

CYP3A4; cytochrome P450; family 3; subfamily A; polypeptide 4; HGNC:2637; CP33; CP34; CYP3A; CYP3A3; HLP; NF-25; P450C3; P450PCN1; P450-III; steroid inducible; cytochrome P450; subfamily IIIA (niphedipine oxidase); polypeptide 3; cytochrome P450; subfamily IIIA (niphedipine oxidase); polypeptide 4; cytochrome P450; subfamily IIIA; polypeptide 4; glucocorticoid-inducible P450; nifedipine oxidase; CYP3A4; cytochrome P450, family 3, subfamily A, polypeptide 4; HGNC:2637; CP33; CP34; CYP3A; CYP3A3; HLP; NF-25; P450C3; P450PCN1; P450-III, steroid inducible; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4; cytochrome P450, subfamily IIIA, polypeptide 4; glucocorticoid-inducible P450; nifedipine oxidase

other names :

cytochrome P450 3A4 isoform 1; Cytochrome P450 3A4; cytochrome P450 3A4; nifedipine oxidase; cytochrome P450 3A3; cytochrome P450 HLp; cytochrome P450-PCN1; cytochrome P450 NF-25; albendazole sulfoxidase; quinine 3-monooxygenase; albendazole monooxygenase; P450-III, steroid inducible; glucocorticoid-inducible P450; 1,8-cineole 2-exo-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4; cytochrome P450, family 3, subfamily A, polypeptide 4; 1,8-cineole 2-exo-monooxygenase (EC:1.14.13.157); Albendazole monooxygenase (EC:1.14.13.32); Albendazole sulfoxidase; CYPIIIA3; CYPIIIA4; Cytochrome P450 3A3; Cytochrome P450 HLp; Cytochrome P450 NF-25; Cytochrome P450-PCN1; Nifedipine oxidase; Quinine 3-monooxygenase (EC:1.14.13.67); Taurochenodeoxycholate 6-alpha-hydroxylase (EC:1.14.13.97)

products gene name :

CYP3A4

other gene names :

CYP3A4; CYP3A4; HLP; CP33; CP34; CYP3A; NF-25; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1; CYP3A3

uniprot entry name :

CP3A4_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Human

sequence length :

503

sequence :

KESRLEDTQKHR

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA)

app notes :

Western Blot: Preliminary experiments gave an approx 26-27kDa band in human liver lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 57.3kDa according to NP_059488.2. The 26-27kDa band was successfully blocked by incubation with the immunizing peptide. Peptide ELISA: antibody detection limit dilution 1:8000.

other info1 :

Epitope: Internal Region. Immunogen: Peptide with sequence C-KESRLEDTQKHR, from the internal region of the protein sequence according to NP_059488.2; NP_001189784.1. Corresponding Immunizing Peptide: Catalog #MBS426504

other info2 :

Important Note: This antibody is expected to recognise both reported isoforms (NP_059488.2; NP_001189784.1) and it is not expected to cross-react with 3A5, 3A7 ot 3A43.

ncbi gi num :

13435386

ncbi acc num :

NP_059488.2

ncbi gb acc num :

NM_017460.5

ncbi mol weight :

57,343 Da

ncbi pathways :

Aflatoxin B1 Metabolism Pathway 198808!!Aflatoxin Activation And Detoxification Pathway 1016173!!Benzo(a)pyrene Metabolism Pathway 198911!!Bile Secretion Pathway 193146!!Bile Secretion Pathway 193095!!Biological Oxidations Pathway 105698!!Chemical Carcinogenesis Pathway 673221!!Chemical Carcinogenesis Pathway 673237!!Codeine And Morphine Metabolism Pathway 198831!!Cytochrome P450 - Arranged By Substrate Type Pathway 105700

ncbi summary :

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011]

size :

0.1 mg

price :

225 USD

more info or order :

MyBioSource product webpage