catalog number :
MBS420551
products full name :
Goat anti-ACOX2 Antibody
products short name :
ACOX2
products name syn :
Goat Anti-ACOX2 (Human) Antibody; ACOX2; acyl-Coenzyme A oxidase 2, branched chain; BCOX; BRCACOX; BRCOX; THCCox; Peroxisomal branched chain acyl-CoA oxidase; THCA-CoA oxidase; Trihydroxycoprostanoyl-CoA oxidase; ACOX2 antibody; acyl-Coenzyme A oxidase 2; branched chain antibody; BCOX antibody; BRCACOX antibody; BRCOX antibody; THCCox antibody; Peroxisomal branched chain acyl-CoA oxidase antibody; THCA-CoA oxidase antibody; Trihydroxycoprostanoyl-CoA oxidase antibody
other names :
peroxisomal acyl-coenzyme A oxidase 2; Peroxisomal acyl-coenzyme A oxidase 2; peroxisomal acyl-coenzyme A oxidase 2; acyl-CoA oxidase 2, branched chain; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase; Trihydroxycoprostanoyl-CoA oxidase; THCA-CoA oxidase; THCCox
products gene name :
ACOX2
other gene names :
ACOX2; ACOX2; BCOX; BRCOX; THCCox; BRCACOX; THCA-CoA oxidase; THCCox
uniprot entry name :
ACOX2_HUMAN
reactivity :
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 32000.
other info1 :
Immunogen: Peptide with sequence C-HQSRLRPSDPEAK, from the internal region (near the C Terminus) of the protein sequence according to NP_003491.1. Epitope: Internal region (near the C Terminus)
other info2 :
Note: Please note this antibody was designed using the mouse sequence, which differs by 1 amino acids from the human sequence.
ncbi acc num :
NP_003491.1
ncbi gb acc num :
NM_003500.3
ncbi mol weight :
76,827 Da
ncbi pathways :
Beta-oxidation Of Pristanoyl-CoA Pathway (1270033); Bile Acid And Bile Salt Metabolism Pathway (1270040); Bile Acid Biosynthesis, Cholesterol = Cholate/chenodeoxycholate Pathway (413432); Bile Acid Biosynthesis, Cholesterol = Cholate/chenodeoxycholate Pathway (468297); Metabolic Pathways (132956); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); PPAR Signaling Pathway (83042); PPAR Signaling Pathway (450); Peroxisomal Lipid Metabolism Pathway (1270031)
ncbi summary :
The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe mental retardation, and death in children. [provided by RefSeq, Mar 2009]
uniprot summary :
ACOX2: Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids. Belongs to the acyl-CoA oxidase family. Protein type: EC 1.17.99.3; Lipid Metabolism - primary bile acid biosynthesis; Oxidoreductase. Chromosomal Location of Human Ortholog: 3p14.3. Cellular Component: intracellular membrane-bound organelle; mitochondrion; peroxisomal matrix; peroxisome. Molecular Function: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity; acyl-CoA binding; acyl-CoA dehydrogenase activity; acyl-CoA oxidase activity; electron carrier activity; FAD binding; fatty acid binding; pristanoyl-CoA oxidase activity; receptor binding. Biological Process: bile acid biosynthetic process; fatty acid beta-oxidation using acyl-CoA dehydrogenase; fatty acid beta-oxidation using acyl-CoA oxidase; lipid homeostasis