Goat anti-KIF5A Antibody | MyBioSource MBS420523 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-KIF5A Antibody

catalog :

MBS420523

quantity :

0.1 mg

price :

225 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420523

products type :

Antibody

products full name :

Goat anti-KIF5A Antibody

products short name :

KIF5A

products name syn :

KIF5A; kinesin family member 5A; NKHC; N-KHC; D12S1889; MY050; SPG10; KIF5A variant protein; kinesin, heavy chain, neuron-specific; KIF5A antibody; kinesin family member 5A antibody; NKHC antibody; N-KHC antibody; D12S1889 antibody; MY050 antibody; SPG10 antibody; KIF5A variant protein antibody; kinesin; heavy chain; neuron-specific antibody

other names :

kinesin heavy chain isoform 5A; Kinesin heavy chain isoform 5A; kinesin heavy chain isoform 5A; kinesin family member 5A; Kinesin heavy chain neuron-specific 1; Neuronal kinesin heavy chain; NKHC

products gene name :

KIF5A

other gene names :

KIF5A; KIF5A; NKHC; MY050; SPG10; D12S1889; NKHC1; NKHC

uniprot entry name :

KIF5A_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow

sequence length :

1032

sequence :

QAKLFPLHQETAAS

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Preliminary experiments gave bands at approx 140, 50, 35 and 20kDa in Human Brain lysates at 1ug of primary. Please note that currently we cannot find an explanation in the literature for the multiple bands we observe given the predicted size of approx.119Kda according to NP_004975.

other info1 :

Immunogen: Peptide with sequence C-QAKLFPLHQETAAS, from the C Terminus of the protein sequence according to NP_004975.2. Epitope: C Terminus

ncbi gi num :

45446749

ncbi acc num :

NP_004975.2

ncbi gb acc num :

NM_004984.2

ncbi mol weight :

117,378 Da

ncbi pathways :

Adaptive Immune System Pathway (1269171); COPI-dependent Golgi-to-ER Retrograde Traffic Pathway (1383042); Dopaminergic Synapse Pathway (469199); Dopaminergic Synapse Pathway (469185); Endocytosis Pathway (102279); Endocytosis Pathway (102181); Factors Involved In Megakaryocyte Development And Platelet Production Pathway (1269377); Golgi-to-ER Retrograde Transport Pathway (1383041); Hemostasis Pathway (1269340); Immune System Pathway (1269170)

ncbi summary :

This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10. [provided by RefSeq, Jul 2008]

uniprot summary :

KIF5A: Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Defects in KIF5A are the cause of spastic paraplegia autosomal dominant type 10 (SPG10). An inherited degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity (stiffness) of the legs. Rate of progression and the severity of symptoms is quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Belongs to the kinesin-like protein family. Kinesin subfamily. Protein type: Motor; Microtubule-binding. Chromosomal Location of Human Ortholog: 12q13.13. Cellular Component: cell soma; ciliary rootlet; cytosol; kinesin complex; membrane; microtubule; neuron projection; perinuclear region of cytoplasm. Molecular Function: ATP binding; microtubule binding; motor activity; plus-end-directed microtubule motor activity; protein binding. Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; axon guidance; cytoskeleton-dependent intracellular transport; metabolic process; microtubule-based movement; protein localization; retrograde vesicle-mediated transport, Golgi to ER; synaptic transmission. Disease: Spastic Paraplegia 10, Autosomal Dominant

size1 :

0.1 mg

price1 :

225 USD

more info or order :

MyBioSource product webpage