Goat anti-ATP6IP2/Renin receptor Antibody | MyBioSource MBS420521 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-ATP6IP2/Renin receptor Antibody

catalog :

MBS420521

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, cow

application :

western blot, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420521

products type :

Antibody

products full name :

Goat anti-ATP6IP2/Renin receptor Antibody

products short name :

ATP6IP2/Renin receptor

products name syn :

ATP6AP2; ATP6IP2; ATPase, H+ transporting, lysosomal interacting protein 2; M8-9; APT6M8-9; ATP6M8-9; renin receptor; V-ATPase M8.9 subunit; ATPase membrane sector associated protein M8-9; vacuolar ATP synthase membrane sector associated protein M8-9; ATP; ATP6AP2 antibody; ATP6IP2 antibody; ATPase; H+ transporting; lysosomal interacting protein 2 antibody; M8-9 antibody; APT6M8-9 antibody; ATP6M8-9 antibody; renin receptor antibody; V-ATPase M8.9 subunit antibody; ATPase membrane sector associated protein M8-9 antibody; vacuolar ATP synthase membrane sector associated protein M8-9 antibody; ATPase; H+ transporting; lysosomal (vacuolar proton pump) membrane sector associated protein M8-9 antibody; ELDF10 antibody; HT028 antibody; MGC99577 antibody; MRXE antibody; MSTP009 antibody; XMRE antibody; ATPase; H+ transporting; lysosomal interacting protein 2 antibody; embryonic liver differentiation factor 10 antibody; Renin receptor; ATP6IP2 / Renin receptor

other names :

renin receptor; Renin receptor; renin receptor; ATPase H+ transporting accessory protein 2; ATPase H(+)-transporting lysosomal accessory protein 2; ATPase H(+)-transporting lysosomal-interacting protein 2; ER-localized type I transmembrane adaptor; Embryonic liver differentiation factor 10; N14F; Renin/prorenin receptor; Vacuolar ATP synthase membrane sector-associated protein M8-9; ATP6M8-9; V-ATPase M8.9 subunit

products gene name :

ATP6AP2

products gene name syn :

ATP6IP2

other gene names :

ATP6AP2; ATP6AP2; PRR; M8-9; MRXE; RENR; XMRE; XPDS; HT028; MRXSH; ELDF10; ATP6IP2; MSTP009; APT6M8-9; ATP6M8-9; ATP6IP2; CAPER; ELDF10; ATP6M8-9; V-ATPase M8.9 subunit

uniprot entry name :

RENR_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human, Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat, Cow

sequence length :

350

sequence :

SIIYRMTNQKIRMD

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 16000. Immunohistochemistry: This antibody has been successfully used on human placenta in the following paper: Pringle et al, J Renin Angiotensin Aldosterone Syst.2010 Aug 11, PMID: 20702505. Western Blot: Approx 37kDa band observed in Human Kidney lysates (calculated MW of 39. 0kDa according to NP_005756.2). Recommended for use at 0.25-1ug/ml.

other info1 :

Immunogen: Peptide with sequence C-SIIYRMTNQKIRMD, from the C Terminus of the protein sequence according to NP_005756.2. Epitope: C Terminus

ncbi gi num :

15011918

ncbi acc num :

NP_005756.2

ncbi gb acc num :

NM_005765.2

ncbi mol weight :

35,612 Da

ncbi pathways :

ACE Inhibitor Pathway (198763); Metabolism Of Angiotensinogen To Angiotensins Pathway (1268749); Metabolism Of Proteins Pathway (1268677); Oxidative Phosphorylation Pathway (198870); Peptide Hormone Metabolism Pathway (1268746); Renin-angiotensin System Pathway (83075); Renin-angiotensin System Pathway (486); Wnt Signaling Network Pathway (137962)

ncbi summary :

This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases. [provided by RefSeq, Jul 2008]

uniprot summary :

ATP6AP2: Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS). Defects in ATP6AP2 are a cause of mental retardation X- linked with epilepsy (MRXE). MRXE is a syndromic mental retardation. Patients manifest mild to moderate mental retardation associated with epilepsy, delays in motor milestones and speech acquisition in infancy. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: Xp11.4. Cellular Component: external side of plasma membrane; integral to membrane; neuron projection; plasma membrane. Molecular Function: enzyme binding; protein binding; receptor activity. Biological Process: angiotensin maturation; eye pigmentation; positive regulation of transforming growth factor-beta1 production; positive regulation of Wnt receptor signaling pathway; regulation of MAPKKK cascade; rostrocaudal neural tube patterning. Disease: Mental Retardation, X-linked, Syndromic, Hedera Type; Parkinsonism With Spasticity, X-linked

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage