catalog number :
MBS420520
products full name :
Goat anti-Arachidonate 5-lipoxygenase Antibody
products short name :
Arachidonate 5-lipoxygenase
products name syn :
arachidonate 5-lipoxygenase; RP11-67C2.3; ALOX5; ALOX5; 5-LO; 5LPG; LOG5; arachidonic acid 5-lipoxygenase; leukotriene A4 synthase; arachidonate 5-lipoxygenase; RP11-67C2.3; ALOX5; 5-LO; 5LPG; LOG5; arachidonic acid 5-lipoxygenase; leukotriene A4 synthase;
other names :
arachidonate 5-lipoxygenase isoform 1; Arachidonate 5-lipoxygenase; arachidonate 5-lipoxygenase; LOX-5; leukotriene A4 synthase; arachidonic acid 5-lipoxygenase; arachidonic 5-lipoxygenase alpha-10 isoform; arachidonic 5-lipoxygenase delta-13 isoform; arachidonic 5-lipoxygenase delta-p10 isoform; arachidonic 5-lipoxygenase delta-10-13 isoform; arachidonate 5-lipoxygenase
products gene name :
ALOX5
other gene names :
ALOX5; ALOX5; 5-LO; 5LPG; LOG5; 5-LOX; LOG5; 5-LO; 5-lipoxygenase
uniprot entry name :
LOX5_HUMAN
reactivity :
Human, Mouse, Rat, Dog
sequence :
ERNKKKQLPYYYLSPD
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 85kDa band observed in Human Bone Marrow and Rat Stomach lysates (calculated MW of 77.7.0kDa according to rat NP_036954). Recommended concentration: 0.3-1ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence C-ERNKKKQLPYYYLSPD, from the C Terminus of the protein sequence according to NP_000689.1.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS426073
ncbi acc num :
NP_000689.1
ncbi gb acc num :
NM_000698.3
ncbi mol weight :
56,291 Da
ncbi pathways :
Arachidonic Acid Metabolism Pathway 82991!!Arachidonic Acid Metabolism Pathway 685553!!Arachidonic Acid Metabolism Pathway 366!!Eicosanoid Synthesis Pathway 198888!!IL-5 Signaling Pathway 198770!!Metabolic Pathways 132956!!Metabolism Pathway 477135!!Metabolism Of Lipids And Lipoproteins Pathway 160976!!Ovarian Steroidogenesis Pathway 790011!!Ovarian Steroidogenesis Pathway 795173
ncbi summary :
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]