catalog number :
MBS420517
products full name :
Goat anti-ARH / LDL receptor adaptor Antibody
products short name :
ARH/LDL receptor adaptor
products name syn :
ARH; LDL receptor adaptor protein; ARH2; FHCB1; FHCB2; MGC34705; DKFZp586D0624; low density lipoprotein receptor adaptor protein 1; RP11-70P17.2; autosomal recessive hypercholesterolemia protein; ARH; LDL receptor adaptor protein; ARH2; FHCB1; FHCB2; MGC34705; DKFZp586D0624; low density lipoprotein receptor adaptor protein 1; RP11-70P17.2; autosomal recessive hypercholesterolemia protein
other names :
low density lipoprotein receptor adapter protein 1; Low density lipoprotein receptor adapter protein 1; low density lipoprotein receptor adapter protein 1; LDL receptor adaptor protein; autosomal recessive hypercholesterolemia protein; low density lipoprotein receptor adaptor protein 1; Autosomal recessive hypercholesterolemia protein
products gene name :
LDLRAP1
other gene names :
LDLRAP1; LDLRAP1; ARH; ARH1; ARH2; FHCB1; FHCB2; ARH
uniprot entry name :
ARH_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 40-45kDa band observed in Human Liver lysate (predicted MW of 35kDa according to NP_056442.1). Recommended for use at 1-3ug/ml. Peptide ELISA: antibody detection limit dilution 1:16000.
other info1 :
Epitope: N Terminus. Immunogen: Peptide with sequence DALKSAGRALIRS-C, from the N Terminus of the protein sequence according to NP_056442.2.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS425951
ncbi acc num :
NP_056442.2
ncbi gb acc num :
NM_015627.2
ncbi mol weight :
33,885 Da
ncbi pathways :
Chylomicron-mediated Lipid Transport Pathway 106157!!Endocytosis Pathway 102279!!Endocytosis Pathway 102181!!LDL-mediated Lipid Transport Pathway 106159!!Lipid Digestion, Mobilization, And Transport Pathway 106111!!Lipoprotein Metabolism Pathway 106156!!Metabolism Pathway 477135!!Metabolism Of Lipids And Lipoproteins Pathway 160976
ncbi summary :
The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia. [provided by RefSeq, Jul 2008]