Goat anti-ATF2 Antibody | MyBioSource MBS420512 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-ATF2 Antibody

catalog :

MBS420512

quantity :

0.1 mg

price :

290 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, rat, dog, cow

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420512

products type :

Antibody

products full name :

Goat anti-ATF2 Antibody

products short name :

ATF2

products name syn :

ATF2; activating transcription factor 2; HB16; CREB2; TREB7; CRE-BP1; cAMP responsive element binding protein 2; MGC111558; activating transcription factor 2 splice variant ATF2-var2; cAMP responsive element binding protein 2; formerly; activating transcription factor 2; HB16; CREB2; TREB7; CRE-BP1; cAMP responsive element binding protein 2; MGC111558; activating transcription factor 2 splice variant ATF2-var2; cAMP responsive element binding protein 2, formerly

other names :

cyclic AMP-dependent transcription factor ATF-2 isoform 1; Cyclic AMP-dependent transcription factor ATF-2; cyclic AMP-dependent transcription factor ATF-2; histone acetyltransferase ATF2; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; cAMP response element-binding protein CRE-BP1; cyclic AMP-responsive element-binding protein 2; cAMP responsive element binding protein 2, formerly; activating transcription factor 2 splice variant ATF2-var2; activating transcription factor 2; Activating transcription factor 2; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding protein 2; HB16; Histone acetyltransferase ATF2; cAMP response element-binding protein CRE-BP1

products gene name :

ATF2

other gene names :

ATF2; ATF2; HB16; CREB2; TREB7; CREB-2; CRE-BP1; CREB2; CREBP1; cAMP-dependent transcription factor ATF-2; CREB-2; cAMP-responsive element-binding protein 2

uniprot entry name :

ATF2_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Human, Rat, Dog, Cow

sequence length :

505

sequence :

IVMAPSSQSQPSGS

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Western Blot: Approx 55kDa and 30kDa bands observed in lysates of Human Placenta. These bands correspond to earlier findings in literature (Bailey et al, J Clin Endocrinol Metab. 2002 Apr;87(4):1717-28.; PMID: 11932306). Approx 75kDa observed in nuclear lysates of cell lines HeLa, HepG2 and K562 (calculated MW of 54.5kDa according to NP_001871.2). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Knippen et al, Anticancer Res. 2009 Jan;29(1):183-189 ; PMID: 19331149). Recommended concentration: 0.3-1ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.

other info1 :

Epitope: C Terminus. Immunogen: Peptide with sequence C-IVMAPSSQSQPSGS, from the C Terminus of the protein sequence according to NP_001871.2.

other info2 :

Corresponding Immunizing Peptide: Catalog #MBS425508

ncbi gi num :

22538422

ncbi acc num :

NP_001871.2

ncbi gb acc num :

NM_001880.3

ncbi mol weight :

15,409 Da

ncbi pathways :

AGE/RAGE Pathway 698754!!ATF-2 Transcription Factor Network Pathway 138006!!Activated TLR4 Signalling Pathway 106400!!Activation Of The AP-1 Family Of Transcription Factors Pathway 160139!!Adrenergic Signaling In Cardiomyocytes Pathway 908257!!Adrenergic Signaling In Cardiomyocytes Pathway 909696!!Alcoholism Pathway 585563!!Alcoholism Pathway 587116!!Amphetamine Addiction Pathway 547607!!Amphetamine Addiction Pathway 550546

ncbi summary :

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]

size :

0.1 mg

price :

290 USD

more info or order :

MyBioSource product webpage