catalog number :
MBS420495
products full name :
Goat anti-Gelsolin / GSN Antibody
products short name :
Gelsolin/GSN
products name syn :
GSN; gelsolin; gelsolin (amyloidosis; Finnish type); DKFZp313L0718; Goat Anti-Gelsolin (isoform a); GSN; gelsolin; gelsolin (amyloidosis, Finnish type); DKFZp313L0718
other names :
gelsolin isoform a; Gelsolin; gelsolin; brevin; actin-depolymerizing factor; gelsolin; AGEL; Actin-depolymerizing factor; ADF; Brevin
other gene names :
GSN; GSN; ADF; AGEL; ADF
uniprot entry name :
GELS_HUMAN
reactivity :
Human, Mouse, Rat, Dog
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 90kDa band observed in Human Spleen lysates (calculated MW of 85.7kDa according to NP_000168.1). Recommended concentration: 0.1-0.3ug/ml. Peptide ELISA: antibody detection limit dilution 1:128000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-PRLKDKKMDAHP, from the internal region of the protein sequence according to NP_000168.1; NP_937895.1. Corresponding Immunizing Peptide: Catalog #MBS425251
other info2 :
Important Note: This antibody is expected to recognize both reported isoforms (NP_000168.1 and NP_937895.1).
ncbi acc num :
NP_000168.1
ncbi gb acc num :
NM_000177.4
ncbi mol weight :
81,485 Da
ncbi pathways :
Amyloids Pathway 366238!!Apoptosis Pathway 105648!!Apoptotic Cleavage Of Cellular Proteins Pathway 105678!!Apoptotic Execution Phase Pathway 105677!!Caspase Cascade In Apoptosis Pathway 137974!!Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway 105679!!Coregulation Of Androgen Receptor Activity Pathway 138085!!Disease Pathway 530764!!EGF Receptor (ErbB1) Signaling Pathway 137970!!Fc Gamma R-mediated Phagocytosis Pathway 114228
ncbi summary :
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]