antibody

Goat anti-Melanocortin 3 Receptor Antibody

MBS420478

0.1 mg

300 USD

polyclonal

goat

nonconjugated

western blot, enzyme immunoassay

Antibody

Goat anti-Melanocortin 3 Receptor Antibody

Melanocortin 3 Receptor

melanocortin 3 receptor; MC3R; MC3; BMIQ9; MC3-R; OB20; OQTL; Obesity quantitative trait locus; melanocortin 3 receptor antibody; MC3R antibody; MC3 antibody; BMIQ9 antibody; MC3-R antibody; OB20 antibody; OQTL antibody; Obesity quantitative trait locus antibody; Melanocortin 3 Receptor; Melanocortin 3 Receptor

melanocortin 3 receptor; Melanocortin receptor 3; melanocortin receptor 3; melanocortin 3 receptor

MC3R

MC3R; MC3R; MC3; OB20; OQTL; BMIQ9; MC3-R; MC3-R

MC3R_HUMAN

Polyclonal

Goat

Tested: Human; Expected from sequence similarity: Human

360

SIQKTYLEGDFV

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Approx 40kDa band observed in Human Brain lysates (calculated MW of 40.1kDa according to NP_063941.2). Recommended concentration: 1-3ug/ml.

Immunogen: Peptide with sequence SIQKTYLEGDFV-C, from the N Terminus of the protein sequence according to NP_063941.2. Epitope: N Terminus

17986279

NP_063941.2

NM_019888.2

36,043 Da

Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); G Alpha (s) Signalling Events Pathway (1269575); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); GPCRs, Class A Rhodopsin-like Pathway (198886); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462); Peptide GPCRs Pathway (920907); Peptide GPCRs Pathway (198897); Peptide Ligand-binding Receptors Pathway (1269546)

This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008]

MC3R: Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family. Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 20q13.2-q13.3. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: melanocortin receptor activity; melanocyte stimulating hormone receptor activity; neuropeptide binding; peptide hormone binding; protein binding. Biological Process: circadian regulation of gene expression; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to cyclic nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); homoiothermy; locomotor rhythm; positive regulation of cAMP biosynthetic process; regulation of blood pressure; regulation of heart rate; sodium ion homeostasis. Disease: Body Mass Index Quantitative Trait Locus 9; Mycobacterium Tuberculosis, Susceptibility To

0.1 mg

300 USD