Goat anti-ITPR3 Antibody | MyBioSource MBS420457 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-ITPR3 Antibody

catalog :

MBS420457

quantity :

0.1 mg

price :

225 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, cow

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420457

products type :

Antibody

products full name :

Goat anti-ITPR3 Antibody

products short name :

ITPR3

products name syn :

ITPR3; inositol 1,4,5-triphosphate receptor, type 3; HGNC: 6182; FLJ36205; IP3R; IP3R3; ITPR3 antibody; inositol 1; 4; 5-triphosphate receptor; type 3 antibody; HGNC: 6182 antibody; FLJ36205 antibody; IP3R antibody; IP3R3 antibody

other names :

inositol 1,4,5-trisphosphate receptor type 3; Inositol 1,4,5-trisphosphate receptor type 3; inositol 1,4,5-trisphosphate receptor type 3; inositol 1,4,5-trisphosphate receptor type 3; IP3 receptor isoform 3; IP3R 3; InsP3R3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor

products gene name :

ITPR3

other gene names :

ITPR3; ITPR3; IP3R; IP3R3; IP3R 3; InsP3R3; Type 3 InsP3 receptor

uniprot entry name :

ITPR3_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow

sequence length :

2671

sequence :

DKKERPTDEEGFLH

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 128000. Western Blot: Preliminary experiments gave an approx 60kDa band in Human Adipose, Colon, Duodenum, Heart and Liver lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 304kDa according to NP_002215.1. The 60kDa band was successfully blocked by incubation with the immunizing peptide.

other info1 :

Immunogen: Peptide with sequence C-DKKERPTDEEGFLH, from the internal region of the protein sequence according to NP_002215.2. Epitope: Internal region

other info2 :

Note: No cross-reactivity expected with other types of ITPR

ncbi gi num :

153945846

ncbi acc num :

NP_002215.2

ncbi gb acc num :

NM_002224.3

ncbi mol weight :

304,106 Da

ncbi pathways :

Adaptive Immune System Pathway (1269171); Aldosterone Synthesis And Secretion Pathway (1272485); Aldosterone Synthesis And Secretion Pathway (1285075); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway (1269184); Apoptosis Pathway (83060); Apoptosis Pathway (470); Beta-catenin Independent WNT Signaling Pathway (1269610)

ncbi summary :

This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]

uniprot summary :

IP3R3: a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Expressed in intestinal crypt and villus epithelial cells. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues. Belongs to the InsP3 receptor family. Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Channel, calcium. Chromosomal Location of Human Ortholog: 6p21. Cellular Component: apical part of cell; brush border; cell soma; cytoplasm; cytosol; dendrite; endoplasmic reticulum; endoplasmic reticulum membrane; integral to plasma membrane; membrane; myelin sheath; nuclear outer membrane; nucleolus; nucleoplasm; perinuclear region of cytoplasm; plasma membrane; receptor complex. Molecular Function: calcium ion binding; calcium-release channel activity; inositol 1,3,4,5 tetrakisphosphate binding; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity; inositol hexakisphosphate binding; phosphoinositide binding; protein binding. Biological Process: elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; inositol phosphate-mediated signaling; memory; platelet activation; protein heterooligomerization; protein homooligomerization; regulation of insulin secretion; release of sequestered calcium ion into cytosol; response to calcium ion; sensory perception of bitter taste; sensory perception of sweet taste; sensory perception of umami taste. Disease: Diabetes Mellitus, Insulin-dependent

size1 :

0.1 mg

price1 :

225 USD

more info or order :

MyBioSource product webpage