catalog number :
MBS420453
products full name :
Goat anti-CENTD2 / ARAP1 Antibody
products short name :
CENTD2/ARAP1
products name syn :
ARAP1; CENTD2; centaurin; delta 2; KIAA0782; ARF-GAP; RHO-GAP; ankyrin repeat; and pleckstrin homology domains-containing protein 1; ArfGAP with RhoGAP domain; ankyrin repeat and PH domain 1; OTTHUMP00000211462; CENTD2; centaurin, delta 2; KIAA0782; ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1; OTTHUMP00000211462
other names :
arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform a; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; cnt-d2; centaurin-delta-2; centaurin, delta 2; ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1; Centaurin-delta-2; Cnt-d2
products gene name :
ARAP1
other gene names :
ARAP1; ARAP1; CENTD2; CENTD2; KIAA0782; Cnt-d2
uniprot entry name :
ARAP1_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Pig, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)
app notes :
Western Blot: This antibody showed a 150KDa in NIH3T3 lysates. Peptide ELISA: antibody detection limit dilution 1:32000. Immunocytochemistry: This antibody showed staining concentrated at the ruffles over lamellipodia and focal complexes but not at focal adhesions in NIH3T3 cells.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence C-AFTADPLSLLRNV, from the C Terminus of the protein sequence according to NP_056057.2; NP_001035207.1; NP_001128662.1. Corresponding Immunizing Peptide: Catalog #MBS425671
other info2 :
Important Note: This antibody is expected to recognise isoform a (NP_056057.2), isoform c (NP_001035207.1) and isoform d (NP_001128662.1).
ncbi acc num :
NP_056057.2
ncbi gb acc num :
NM_015242.4
ncbi mol weight :
127,665 Da
ncbi pathways :
Endocytosis Pathway 102279!!Endocytosis Pathway 102181!!Regulation Of RhoA Activity Pathway 138070!!Rho GTPase Cycle Pathway 106503!!Signal Transduction Pathway 477114!!Signaling By Rho GTPases Pathway 106502
ncbi summary :
The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]