catalog number :
MBS420452
products full name :
Goat anti-PIK3C2A Antibody
products short name :
PIK3C2A
products name syn :
PIK3C2A; CPK; PI3-K-C2A; PI3K-C2alpha; PI3-K-C2(ALPHA); phosphoinositide-3-kinase; class 2; alpha polypeptide; C2-containing phosphatidylinositol kinase; DKFZp686L193; MGC142218; PIK3C2A; CPK; PI3-K-C2A; PI3K-C2alpha; PI3-K-C2(ALPHA); phosphoinositide-3-kinase, class 2, alpha polypeptide; C2-containing phosphatidylinositol kinase; DKFZp686L193; MGC142218;
other names :
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; PI3K-C2alpha; PI3K-C2-alpha; ptdIns-3-kinase C2 subunit alpha; phosphoinositide 3-kinase-C2-alpha; C2-containing phosphatidylinositol kinase; phosphoinositide-3-kinase, class 2, alpha polypeptide; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha; phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha; Phosphoinositide 3-kinase-C2-alpha
products gene name :
PIK3C2A
other gene names :
PIK3C2A; PIK3C2A; CPK; PI3-K-C2A; PI3-K-C2(ALPHA); PI3K-C2-alpha; PtdIns-3-kinase C2 subunit alpha
uniprot entry name :
P3C2A_HUMAN
reactivity :
Human, Mouse, Dog
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
app notes :
Immunohistochemistry: In paraffin embedded Human Heart shows strong staining of the capillary network and patterned staining of the myocardial fibres in transverse section. Recommended concentration, 5-10ug/ml. Western Blot: Preliminary experiments gave no signal but low background in Human Testis and Molt-4 lysates at up to 1ug/ml. Peptide ELISA: antibody detection limit dilution 1:32000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence C-TVKWYQLTAATYL, from the C Terminus of the protein sequence according to NP_002636.2.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS426184
ncbi acc num :
NP_002636.2
ncbi gb acc num :
NM_002645.2
ncbi mol weight :
53,742 Da
ncbi pathways :
3-phosphoinositide Biosynthesis Pathway 545314!!3-phosphoinositide Biosynthesis Pathway 138600!!Clathrin Derived Vesicle Budding Pathway 119545!!Golgi Associated Vesicle Biogenesis Pathway 119546!!Inositol Phosphate Metabolism Pathway 82987!!Inositol Phosphate Metabolism Pathway 362!!Insulin Signaling Pathway 198845!!Integrins In Angiogenesis Pathway 137999!!Membrane Trafficking Pathway 106160!!Metabolic Pathways 132956
ncbi summary :
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]