catalog number :
MBS420432
products full name :
Goat anti-BARK1 / GRK2 Antibody
products short name :
BARK1/GRK2
products name syn :
BARK1; GRK2; ADRBK1; adrenergic; beta; receptor kinase 1; BETA-ARK1; beta adrenergic receptor kinase 1; BARK1; GRK2; adrenergic, beta, receptor kinase 1; BETA-ARK1; beta adrenergic receptor kinase 1
other names :
beta-adrenergic receptor kinase 1; Beta-adrenergic receptor kinase 1; beta-adrenergic receptor kinase 1; beta-ARK-1; G-protein coupled receptor kinase 2; adrenergic, beta, receptor kinase 1; G-protein coupled receptor kinase 2
products gene name :
ADRBK1
other gene names :
ADRBK1; ADRBK1; GRK2; BARK1; BETA-ARK1; BARK; BARK1; GRK2; Beta-ARK-1
uniprot entry name :
ARBK1_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Pig, Cow
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Western Blot: Approx 75-80kDa band observed in Human lysates of Burkitt's lymphoma cell line Daudi (calculated MW of 79.7kDa according to NP_001610.1). Recommended concentration: 0.3-1.0ug/ml. Peptide ELISA: antibody detection limit dilution 1:16000.
other info1 :
Epitope: Internal Region. Immunogen: Peptide with sequence C-RDAYREAQQLVQR, from the internal region of the protein sequence according to NP_001610.2.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS425244
ncbi acc num :
NP_001610.2
ncbi gb acc num :
NM_001619.3
ncbi mol weight :
79,574 Da
ncbi pathways :
CXCR4-mediated Signaling Events Pathway 137910!!Ca-dependent Events Pathway 106497!!CaM Pathway 106468!!Calmodulin Induced Events Pathway 106469!!Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!DAG And IP3 Signaling Pathway 477115!!DAP12 Interactions Pathway 685549!!DAP12 Signaling Pathway 685550!!Disease Pathway 530764
ncbi summary :
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008]