catalog number :
MBS420420
products full name :
Goat anti-PP2A / PPP2R1A Antibody
products short name :
PP2A/PPP2R1A
products name syn :
PPP2R1A; MGC786; protein phosphatase 2 (formerly 2A); regulatory subunit A (PR 65); alpha isoform; PP2A; subunit A; R1-alpha isoform; PP2A; subunit A; PR65-alpha isoform; medium tumor antigen-associated 61 KDA protein; Serine/threonine protein phosphatase 2A; 65 KDA regulatory subunit A; alpha isoform; protein phosphatase 2 (formerly 2A); regulatory subunit A; alpha isoform; PR65A; alpha isoform of regulatory subunit A; protein phosphatase 2; medium tumor antigen-associated 61 KDA protein; protein phosphatase 2 (formerly 2A); regulatory subunit A (PR 65); alpha isoform; PPP2R1A; MGC786; protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform; PP2A, subunit A, R1-alpha isoform; PP2A, subunit A, PR65-alpha isoform; medium tumor antigen-associated 61 KDA protein; Serine/threonine protein phosphatase 2A, 65 KDA regulatory subunit A, alpha isoform; protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform; PR65A; alpha isoform of regulatory subunit A, protein phosphatase 2; medium tumor antigen-associated 61 KDA protein; protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform
other names :
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; PP2A subunit A isoform R1-alpha; PP2A subunit A isoform PR65-alpha; medium tumor antigen-associated 61 KDA protein; protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform; serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alpha isoform; protein phosphatase 2, regulatory subunit A, alpha; Medium tumor antigen-associated 61 kDa protein; PP2A subunit A isoform PR65-alpha; PP2A subunit A isoform R1-alpha
products gene name :
PPP2R1A
other gene names :
PPP2R1A; PPP2R1A; PR65A; PP2AAALPHA; PP2A-Aalpha
uniprot entry name :
2AAA_HUMAN
reactivity :
Human, Mouse, Rat, Dog, Pig, Cow
sequence :
KYFAQEALTVLSLA
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Immunohistochemistry: In paraffin embedded Human Thyroid Gland shows textured cytoplasm and membranous staining in the epithelial cells. Recommended concentration, 3-6ug/ml. Western Blot: Approx 60kDa band observed in Human Thymus and Lymph Node lysates and in lysates of Mouse and Rat Brain and of cell line NIH3T3 (calculated MW of 65.3kDa according to NP_055040.2). Recommended concentration: 0.03-0.1ug/ml. Peptide ELISA: antibody detection limit dilution 1:16000.
other info1 :
Epitope: C Terminus. Immunogen: Peptide with sequence C-KYFAQEALTVLSLA, from the C Terminus of the protein sequence according to NP_055040.2.
other info2 :
Corresponding Immunizing Peptide: Catalog #MBS426061
ncbi acc num :
NP_055040.2
ncbi gb acc num :
NM_014225.5
ncbi mol weight :
65,309 Da
ncbi pathways :
AMER1 Mutants Destabilize The Destruction Complex Pathway 1016198!!AMPK Signaling Pathway 989139!!AMPK Signaling Pathway 992181!!APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway 1016193!!APC Truncation Mutants Have Impaired AXIN Binding Pathway 1016194!!AXIN Missense Mutants Destabilize The Destruction Complex Pathway 1016197!!AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway 1016195!!Activated TLR4 Signalling Pathway 106400!!Adaptive Immune System Pathway 366160!!Adrenergic Signaling In Cardiomyocytes Pathway 908257
ncbi summary :
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]