Goat anti-NODAL Antibody | MyBioSource MBS420416 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-NODAL Antibody

catalog :

MBS420416

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420416

products type :

Antibody

products full name :

Goat anti-NODAL Antibody

products short name :

NODAL

products name syn :

NODAL; nodal homolog (mouse); MGC138230; mouse nodal homolog precursor; nodal, mouse, homolog; NODAL antibody; nodal homolog (mouse) antibody; MGC138230 antibody; mouse nodal homolog precursor antibody; nodal; mouse; homolog antibody

other names :

nodal; Nodal homolog; nodal homolog; nodal growth differentiation factor

products gene name :

NODAL

other gene names :

NODAL; NODAL; HTX5

uniprot entry name :

NODAL_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat

sequence length :

347

sequence :

ECPNPVGEEFH

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), ELISA (EIA)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 8000. Enzyme immunoassay: Sandwich-type ELISA with increasing amount of recombinant NODAL captured by a rabbit antibody. Recommended reporter concentration: 1-2ug/ml.

other info1 :

Immunogen: Peptide with sequence ECPNPVGEEFH, from the internal region of the protein sequence according to NP_060525.2. Epitope: Internal region

ncbi gi num :

29568107

ncbi acc num :

NP_060525.2

ncbi gb acc num :

NM_018055.3

ncbi mol weight :

39,561 Da

ncbi pathways :

Cardiac Progenitor Differentiation Pathway (712094); Developmental Biology Pathway (1270302); Integrated Pancreatic Cancer Pathway (711360); Regulation Of Signaling By NODAL Pathway (1270344); Signaling By NODAL Pathway (1270343); Signaling Pathways Regulating Pluripotency Of Stem Cells (1026136); Signaling Pathways Regulating Pluripotency Of Stem Cells (1033502); TGF-beta Signaling Pathway (83064); TGF-beta Signaling Pathway (475)

ncbi summary :

The protein encoded by this gene is a member of the TGF-beta superfamily. Studies of the mouse counterpart suggested that this gene may be essential for mesoderm formation and subsequent organization of axial structures in early embryonic development. [provided by RefSeq, Jul 2008]

uniprot summary :

NODAL: Essential for mesoderm formation and axial patterning during embryonic development. Defects in NODAL are the cause of visceral heterotaxy autosomal type 5 (HTX5). A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. It results in an abnormal arrangement of visceral organs, and a wide variety of congenital defects. Clinical features of visceral heterotaxy autosomal type 5 include situs inversus viscerum or situs ambiguus, congenital heart defect, transposition of the great vessels ventricular septal defect, atrial septal defect, truncuscommunis, and dextrocardia. Belongs to the TGF-beta family. Protein type: Motility/polarity/chemotaxis; Secreted; Cytokine; Secreted, signal peptide; Cell development/differentiation. Chromosomal Location of Human Ortholog: 10q22.1. Cellular Component: extracellular space. Molecular Function: cytokine activity; growth factor activity; morphogen activity; receptor agonist activity; transforming growth factor beta receptor binding. Biological Process: axial mesodermal cell fate specification; BMP signaling pathway; brain development; cell migration involved in gastrulation; digestive tract morphogenesis; embryonic cranial skeleton morphogenesis; embryonic pattern specification; embryonic placenta development; embryonic process involved in female pregnancy; floor plate morphogenesis; formation of anatomical boundary; heart looping; liver development; maternal placenta development; maternal process involved in parturition; mesendoderm development; negative regulation of transcription from RNA polymerase II promoter; neural fold formation; placenta development; polarity specification of proximal/distal axis; positive regulation of activin receptor signaling pathway; positive regulation of angiogenesis; positive regulation of caspase activity; positive regulation of cell-cell adhesion; positive regulation of epithelial cell proliferation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; regulation of gastrulation; repression of premature neural plate formation; stem cell maintenance; trophectodermal cellular morphogenesis; vasculature development. Disease: Heterotaxy, Visceral, 5, Autosomal

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage