catalog number :
MBS420413
products full name :
Goat anti-CBX8 Antibody
products short name :
CBX8
products name syn :
CBX8; chromobox homolog 8 (Pc class homolog, Drosophila); HPC3; PC3; RC1; chromobox homolog 8; polycomb 3; CBX8 antibody; chromobox homolog 8 (Pc class homolog; Drosophila) antibody; HPC3 antibody; PC3 antibody; RC1 antibody; chromobox homolog 8 antibody; polycomb 3 antibody
other names :
chromobox protein homolog 8; Chromobox protein homolog 8; chromobox protein homolog 8; chromobox 8; Polycomb 3 homolog; Pc3; hPc3; Rectachrome 1
products gene name :
CBX8
other gene names :
CBX8; CBX8; PC3; RC1; PC3; RC1; Pc3; hPc3
uniprot entry name :
CBX8_HUMAN
reactivity :
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Pig, Cow
sequence :
RERGTSRVDDKPSS
purity :
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
form :
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
concentration :
100ug specific antibody in 200ul
storage stability :
Aliquot and store at -20 degree C. Minimize freezing and thawing.
tested application :
Peptide ELISA (EIA), Western Blot (WB)
app notes :
Peptide ELISA: Antibody detection limit dilution 1: 32000.
other info1 :
Immunogen: Peptide with sequence C-RERGTSRVDDKPSS, from the internal region of the protein sequence according to NP_065700.1. Epitope: Internal region
ncbi acc num :
NP_065700.1
ncbi gb acc num :
NM_020649.2
ncbi mol weight :
43,396 Da
ncbi pathways :
Cellular Senescence Pathway (1270426); Cellular Responses To Stress Pathway (1270414); Metabolism Of Proteins Pathway (1268677); Oxidative Stress Induced Senescence Pathway (1270428); Post-translational Protein Modification Pathway (1268701); SUMO E3 Ligases SUMOylate Target Proteins Pathway (1268743); SUMOylation Pathway (1268738); SUMOylation Of DNA Damage Response And Repair Proteins Pathway (1268744); SUMOylation Of RNA Binding Proteins Pathway (1339112)
uniprot summary :
CBX8: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Protein type: Transcription, coactivator/corepressor. Chromosomal Location of Human Ortholog: 17q25.3. Cellular Component: heterochromatin; nuclear chromatin; nucleoplasm; nucleus; PcG protein complex. Molecular Function: methylated histone residue binding; protein binding; single-stranded RNA binding. Biological Process: histone ubiquitination; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of DNA repair; protein sumoylation; regulation of catalytic activity; transcription, DNA-dependent