Goat anti-MBL2/Mannan-Binding Lectin Antibody | MyBioSource MBS420391 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-MBL2/Mannan-Binding Lectin Antibody

catalog :

MBS420391

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420391

products type :

Antibody

products full name :

Goat anti-MBL2/Mannan-Binding Lectin Antibody

products short name :

MBL2/Mannan-Binding Lectin

products name syn :

MBL2; mannan-binding lectin; MBL; MBP; MBP1; COLEC1; HSMBPC; mannose-binding lectin (protein C) 2, soluble (opsonic defect); mannan-binding protein; mannose binding protein; Mannose-binding lectin 2, soluble (opsonic defect); MGC116832; MGC116833; mannose; MBL2 antibody; mannan-binding lectin antibody; MBL antibody; MBP antibody; MBP1 antibody; COLEC1 antibody; HSMBPC antibody; mannose-binding lectin (protein C) 2; soluble (opsonic defect) antibody; mannan-binding protein antibody; mannose binding protein antibody; Mannose-binding lectin 2; soluble (opsonic defect) antibody; Mannan-Binding Lectin; MBL2 / Mannan-Binding Lectin

other names :

mannose-binding protein C; Mannose-binding protein C; mannose-binding protein C; mannose binding lectin 2; Collectin-1; MBP1; Mannan-binding protein; Mannose-binding lectin

products gene name :

MBL2

other gene names :

MBL2; MBL2; MBL; MBP; MBP1; MBPD; MBL2D; MBP-C; COLEC1; HSMBPC; COLEC1; MBL; MBP-C

uniprot entry name :

MBL2_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human; Expected from sequence similarity: Human

sequence length :

248

sequence :

STSHLAVCEFPI

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 4000. Western Blot: Approx 26kDa band observed in Human Heart and Human Kidney lysates (calculated MW of 26.1kDa according to NP_000233). Recommended concentration: 1-3ug/ml.

other info1 :

Immunogen: Peptide with sequence STSHLAVCEFPI, from the C Terminus of the protein sequence according to NP_000233.1. Epitope: C Terminus

ncbi gi num :

4557739

ncbi acc num :

NP_000233.1

ncbi gb acc num :

NM_000242.2

ncbi mol weight :

26,144 Da

ncbi pathways :

Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (1269241); Creation Of C4 And C2 Activators Pathway (1269243); Immune System Pathway (1269170); Initial Triggering Of Complement Pathway (1269242); Innate Immune System Pathway (1269203); Lectin Pathway Of Complement Activation (1269244); Phagosome Pathway (153910); Phagosome Pathway (153859)

ncbi summary :

This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008]

uniprot summary :

MBL2: Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 10q11.2. Cellular Component: cell surface; collagen; extracellular region; extracellular space. Molecular Function: calcium ion binding; calcium-dependent protein binding; mannose binding; protein binding; receptor binding; serine-type endopeptidase activity. Biological Process: acute-phase response; complement activation; complement activation, classical pathway; complement activation, lectin pathway; defense response to bacterium; defense response to Gram-positive bacterium; innate immune response; killing by host of symbiont cells; negative regulation of viral reproduction; opsonization; positive regulation of phagocytosis; proteolysis; response to oxidative stress. Disease: Mannose-binding Protein Deficiency

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage