Goat anti-NMDAR2B/GRIN2B Antibody | MyBioSource MBS420388 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-NMDAR2B/GRIN2B Antibody

catalog :

MBS420388

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog

application :

western blot, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420388

products type :

Antibody

products full name :

Goat anti-NMDAR2B/GRIN2B Antibody

products short name :

NMDAR2B/GRIN2B

products name syn :

GRIN2B; NMDAR2B; glutamate receptor, ionotropic, N-methyl D-aspartate 2B; HGNC: 4586; NR2B; hNR3; N-methyl-D-aspartate receptor subunit 2B; GRIN2B antibody; NMDAR2B antibody; glutamate receptor; ionotropic; N-methyl D-aspartate 2B antibody; HGNC: 4586 antibody; NR2B antibody; hNR3 antibody; N-methyl-D-aspartate receptor subunit 2B antibody; NMDAR2B / GRIN2B

other names :

N-methyl-D-aspartate receptor subunit 2B; Glutamate receptor ionotropic, NMDA 2B; glutamate receptor ionotropic, NMDA 2B; glutamate ionotropic receptor NMDA type subunit 2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B; N-methyl-D-aspartate receptor subunit 3; NR3; hNR3

products gene name :

GRIN2B

products gene name syn :

NMDAR2B

other gene names :

GRIN2B; GRIN2B; MRD6; NR2B; hNR3; EIEE27; GluN2B; NMDAR2B; NMDAR2B; GluN2B; NMDAR2B; NR2B; NR3; hNR3

uniprot entry name :

NMDE2_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog

sequence length :

1484

sequence :

KDAHEKDDFHHLS

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Approx 170kDa band observed in Rat Brain lysates (calculated MW of 166kDa according to NP_000825.1). Recommended concentration: 2-4ug/ml.

other info1 :

Immunogen: Peptide with sequence C-KDAHEKDDFHHLS, from the internal region of the protein sequence according to NP_000825.1. Epitope: Internal region

ncbi gi num :

4504127

ncbi acc num :

NP_000825.1

ncbi gb acc num :

NM_000834.2

ncbi mol weight :

166,367 Da

ncbi pathways :

ARMS-mediated Activation Pathway (1269471); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (1268798); Alcoholism Pathway (585563); Alcoholism Pathway (587116); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099)

ncbi summary :

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008]

uniprot summary :

NMDAR2B: an NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium. Chromosomal Location of Human Ortholog: 12p12. Cellular Component: cell junction; cell surface; integral to plasma membrane; intracellular; N-methyl-D-aspartate selective glutamate receptor complex; neuron projection; plasma membrane; postsynaptic membrane. Molecular Function: extracellular-glutamate-gated ion channel activity; glycine binding; N-methyl-D-aspartate selective glutamate receptor activity; protein binding; Ras guanyl-nucleotide exchange factor activity; zinc ion binding. Biological Process: ephrin receptor signaling pathway; glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; learning and/or memory; MAPKKK cascade; positive regulation of GTPase activity; response to ethanol; synaptic transmission; transport. Disease: Epileptic Encephalopathy, Early Infantile, 27; Mental Retardation, Autosomal Dominant 6

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage