Goat anti-Proopiomelanocortin/POMC Antibody | MyBioSource MBS420379 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-Proopiomelanocortin/POMC Antibody

catalog :

MBS420379

quantity :

0.1 mg

price :

300 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS420379

products type :

Antibody

products full name :

Goat anti-Proopiomelanocortin/POMC Antibody

products short name :

Proopiomelanocortin/POMC

products name syn :

POMC; proopiomelanocortin; Precursor of MSH, POC, ACTH, CLIP, adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating; hormone/ beta-endorphin; LPH; NPP; OTTHUMP00000119991; OTTHUMP00000200964; adrenocortic; POMC antibody; proopiomelanocortin antibody; Precursor of MSH; POC; ACTH; CLIP; adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin antibody; LPH antibody; NPP antibody; OTTHUMP00000119991 antibody; OTTHUMP00000200964 antibody; adrenocorticotropic hormone antibody; adrenocorticotropin antibody; alpha-melanocyte-stimulating hormone antibody; beta-LPH antibody; beta-MSH antibody; beta-melanocyte-stimulating hormone antibody; corticotropin-like intermediary peptide antibody; gamma-LPH antibody; gamma-MSH antibody; lipotropin beta antibody; lipotropin gamma antibody; melanotropin alpha antibody; melanotropin beta antibody; melanotropin gamma antibody; met-enkephalin antibody; pro-ACTH-endorphin antibody; proopiomelanocortin preproprotein antibody; Proopiomelanocortin; Proopiomelanocortin / POMC

other names :

pro-opiomelanocortin preproprotein; Pro-opiomelanocortin; pro-opiomelanocortin; proopiomelanocortin; Corticotropin-lipotropin

products gene name :

POMC

other gene names :

POMC; POMC; LPH; MSH; NPP; POC; ACTH; CLIP; POMC; ACTH; CLIP

uniprot entry name :

COLI_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat

sequence length :

267

sequence :

NAIIKNAYKKGE

purity :

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

form :

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

concentration :

100ug specific antibody in 200ul

storage stability :

Aliquot and store at -20 degree C. Minimize freezing and thawing.

tested application :

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Peptide ELISA: Antibody detection limit dilution 1: 128000. Immunohistochemistry: In paraffin embedded Human Anterior Pituitary Gland shows vesilulate staining in glandular cells. Recommended concentration, 2-4ug/ml. Western Blot: Approx 29kDa band observed in lysates of cell line NIH3T3 (calculated MW of 29.4kDa according to NP_000930.1 and NP_001030333.1). Recommended concentration: 0.1-0.3ug/ml.

other info1 :

Immunogen: Peptide with sequence C-NAIIKNAYKKGE, from the C Terminus of the protein sequence according to NP_000930.1; NP_001030333.1. Epitope: C Terminus

other info2 :

Note: Both transcript variants encode the same protein. In Western blot, this product appears to react with the full length precursor protein only.

ncbi gi num :

4505949

ncbi acc num :

NP_000930.1

ncbi gb acc num :

NM_000939.3

ncbi mol weight :

29,424 Da

ncbi pathways :

Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Androgen Biosynthesis Pathway (1270050); Biological Oxidations Pathway (1270189); Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); Corticotropin-releasing Hormone Pathway (920957); Cytochrome P450 - Arranged By Substrate Type Pathway (1270191); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1269004); Disease Pathway (1268854); Diseases Of Metabolism Pathway (1268939)

ncbi summary :

This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jan 2016]

uniprot summary :

POMC: ACTH stimulates the adrenal glands to release cortisol. Defects in POMC may be associated with susceptibility to obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD). Affected individuals present early-onset obesity, adrenal insufficiency and red hair. Belongs to the POMC family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 2p23.3. Cellular Component: cytoplasm; extracellular region; extracellular space; peroxisomal matrix; peroxisome; secretory granule. Molecular Function: G-protein-coupled receptor binding; hormone activity; neuropeptide hormone activity; receptor binding; type 3 melanocortin receptor binding; type 4 melanocortin receptor binding. Biological Process: cell-cell signaling; cellular pigmentation; generation of precursor metabolites and energy; glucose homeostasis; negative regulation of tumor necrosis factor production; neuropeptide signaling pathway; peptide hormone processing; positive regulation of transcription from RNA polymerase II promoter; regulation of appetite; regulation of blood pressure; signal transduction. Disease: Obesity; Proopiomelanocortin Deficiency

size1 :

0.1 mg

price1 :

300 USD

more info or order :

MyBioSource product webpage