antibody

Goat anti-OASIS/CREB3L1 Antibody

MBS420370

0.1 mg

300 USD

polyclonal

goat

nonconjugated

human, mouse, rat

western blot, enzyme immunoassay

Antibody

Goat anti-OASIS/CREB3L1 Antibody

OASIS/CREB3L1

CREB3L1; OASIS; cAMP responsive element binding protein 3-like 1; BBF-2 (drosophila) homolog; old astrocyte specifically induced substance; BBF-2 homolog; CREB3L1 antibody; OASIS antibody; cAMP responsive element binding protein 3-like 1 antibody; BBF-2 (drosophila) homolog antibody; old astrocyte specifically induced substance antibody; BBF-2 homolog antibody; OASIS / CREB3L1

cyclic AMP-responsive element-binding protein 3-like protein 1; Cyclic AMP-responsive element-binding protein 3-like protein 1; cyclic AMP-responsive element-binding protein 3-like protein 1; cAMP responsive element binding protein 3-like 1; Old astrocyte specifically-induced substance; OASIS

CREB3L1

CREB3L1; CREB3L1; OASIS; OASIS; cAMP-responsive element-binding protein 3-like protein 1; OASIS

CR3L1_HUMAN

Polyclonal

Goat

Tested: Human; Expected from sequence similarity: Human, Mouse, Rat

519

DFSHSKEWFHDRD

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Approx 60kDa band observed in lysates of cell line A549 (calculated MW of 57. 0kDa according to NP_443086.1). Recommended concentration: 1-3ug/ml.

Immunogen: Peptide with sequence C-DFSHSKEWFHDRD, from the C Terminus of the protein sequence according to NP_443086.1. Epitope: C Terminus

16418355

NP_443086.1

NM_052854.3

47,783 Da

AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Alcoholism Pathway (585563); Alcoholism Pathway (587116); Aldosterone Synthesis And Secretion Pathway (1272485); Aldosterone Synthesis And Secretion Pathway (1285075); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546)

The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013]

CREB3L1: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE. Belongs to the bZIP family. ATF subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor; Membrane protein, integral. Chromosomal Location of Human Ortholog: 11p11.2. Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; nucleus. Molecular Function: chromatin binding; protein binding; sequence-specific DNA binding. Biological Process: multicellular organismal development; osteoblast differentiation; transcription from RNA polymerase II promoter; unfolded protein response

0.1 mg

300 USD