antibody

Goat anti-SCN5A Antibody

MBS420367

0.1 mg

225 USD

polyclonal

goat

nonconjugated

human, mouse, rat, dog, cow

ELISA, enzyme immunoassay

Antibody

Goat anti-SCN5A Antibody

SCN5A

Goat Anti-SCN5A (aa1021-1034) Antibody; SCN5A; CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; ICCD; HH1; IVF; LQT3; SSS1; PFHB1; SSS1; sodium channel, voltage-gated, type V, alpha subunit; Nav1.5; sodium channel, voltage-gated, type V, alpha (long QT syndrome 3); cardiac sodium channel alpha subunit; sod; SCN5A antibody; CDCD2 antibody; CMD1E antibody; CMPD2 antibody; HB1 antibody; HB2 antibody; HBBD antibody; ICCD antibody; HH1 antibody; IVF antibody; LQT3 antibody; SSS1 antibody; PFHB1 antibody; SSS1 antibody; sodium channel; voltage-gated; type V; alpha subunit antibody; Nav1.5 antibody; sodium channel; voltage-gated; type V; alpha (long QT syndrome 3) antibody; cardiac sodium channel alpha subunit antibody; sodium channel; voltage-gated; type V; alpha polypeptide (long (electrocardiographic) QT syndrome 3) antibody; VF1 antibody; cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit antibody; sodium channel protein type V alpha subunit antibody; voltage-gated sodium channel type V alpha antibody

sodium channel protein type 5 subunit alpha isoform a; Sodium channel protein type 5 subunit alpha; sodium channel protein type 5 subunit alpha; sodium voltage-gated channel alpha subunit 5; HH1; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein type V subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.5

SCN5A

SCN5A; SCN5A; HB1; HB2; HH1; IVF; VF1; HBBD; ICCD; LQT3; SSS1; CDCD2; CMD1E; CMPD2; PFHB1; Nav1.5

SCN5A_HUMAN

Polyclonal

Goat

Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow

2016

ETDDQSPEKIN

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Peptide ELISA (EIA)

Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Preliminary experiments in lysates of Human Breast and Heart tissues gave no specific signal but low background (at antibody concentration up to 1ug/ml).

Immunogen: Peptide with sequence C-ETDDQSPEKIN, from the internal region of the protein sequence according to NP_932173.1; NP_000326.2; NP_001092874.1; NP_001092875.1; NP_001153632.1; NP_001153633.1. Epitope: Internal region

Note: This antibody is expected to recognise all reported isoforms (NP_932173.1; NP_000326.2; NP_001092874.1; NP_001092875.1).

37622907

NP_932173.1

NM_198056.2

224,917 Da

Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Axon Guidance Pathway (1270303); Cardiac Progenitor Differentiation Pathway (712094); Cardiac Conduction Pathway (1339115); Developmental Biology Pathway (1270302); Interaction Between L1 And Ankyrins Pathway (1270325); L1CAM Interactions Pathway (1270323); Muscle Contraction Pathway (1269868); Phase 0 - Rapid Depolarisation Pathway (1339117)

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

SCN5A: an integral membrane protein and a voltage-gated sodium channel subunit. Mediates the voltage-dependent sodium ion permeability of excitable membranes. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. Intracellular calcium levels regulate channel inactivation. Interacts with the PDZ domain of the syntrophin SNTA1, SNTB1 and SNTB2. Interacts with NEDD4, NEDD4L, WWP2 and GPD1L. Defects in this protein are a cause of long QT syndrome type 3 (LQT3). Belongs to the sodium channel (TC 1.A.1.10) family, Nav1.5/SCN5A subfamily. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Channel, sodium; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 3p21. Cellular Component: caveola; cell surface; endoplasmic reticulum; integral to membrane; intracellular; lateral plasma membrane; plasma membrane; sarcolemma; T-tubule; voltage-gated sodium channel complex; Z disc. Molecular Function: ankyrin binding; calmodulin binding; enzyme binding; fibroblast growth factor binding; nitric-oxide synthase binding; protein binding; protein domain specific binding; protein kinase binding; ubiquitin protein ligase binding; voltage-gated sodium channel activity. Biological Process: cardiac muscle contraction; cerebellum development; generation of action potential; membrane depolarization; odontogenesis of dentine-containing teeth; positive regulation of action potential; positive regulation of epithelial cell proliferation; regulation of heart rate; regulation of postsynaptic membrane potential; response to denervation involved in regulation of muscle adaptation; sodium ion transport; telencephalon development. Disease: Atrial Fibrillation, Familial, 10; Brugada Syndrome 1; Cardiomyopathy, Dilated, 1e; Long Qt Syndrome 3; Progressive Familial Heart Block, Type Ia; Sick Sinus Syndrome 1, Autosomal Recessive; Sudden Infant Death Syndrome; Ventricular Fibrillation During Myocardial Infarction, Susceptibility To

0.1 mg

225 USD